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Tyrosol (Synonyms: 4-Hydroxyphenylethanol, 4-Hydroxyphenethyl alcohol, 2-(4-Hydroxyphenyl)ethanol)

Name: Tyrosol
Brand: TargetMol
SKU: T2861
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T2861 Copy Product Info

Purity: 99.86%

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Tyrosol (2-(4-Hydroxyphenyl)ethanol) is a phenolic antioxidant that is naturally present in several foods such as wines and green tea and is present most abundantly in olives.

Tyrosol

Copy Product Info

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Catalog No. T2861

Synonyms 4-Hydroxyphenylethanol, 4-Hydroxyphenethyl alcohol, 2-(4-Hydroxyphenyl)ethanol

Tyrosol (2-(4-Hydroxyphenyl)ethanol) is a phenolic antioxidant that is naturally present in several foods such as wines and green tea and is present most abundantly in olives.

Cas No. 501-94-0

Pack Size	Price	USA Stock	Global Stock
100 mg	$35	In Stock	In Stock
500 mg	$73	In Stock	In Stock
1 g	$105	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$45	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.86%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Tyrosol AI Summary

Tyrosol exhibits a wide range of bioactivities across various assays. It has demonstrated cytotoxicity against human HeLa cervical carcinoma cells with a cytotoxicity concentration of 1420.0 µM and against human MM96L melanoma cells with a cytotoxic concentration of 905.0 µM. The compound shows selectivity and strong inhibition towards carbonic anhydrase isoforms (CA 1, 2, 5A, and 5B) and also exhibits inhibitory activity against beta-carbonic anhydrases from pathogens like Mycobacterium tuberculosis and Candida albicans, indicating specificity in enzyme inhibition. Inhibition assays reveal that Tyrosol is a potent Glutaminase (GLS) inhibitor with a potency of 10000.0 nM and also effectively inhibits NADPH oxidase in human endothelial cells (HUVEC) with an IC50 of 7500.0 nM, suggesting potential antioxidant and anti-inflammatory effects. It exhibits moderate antifungal activity against Verticillium dahliae with an IC50 value of 660.0 µg/mL and also shows activity against the diphenolase activity of mushroom tyrosinase with inhibition percentages ranging from 14.31% to 18.73%. Tyrosol demonstrates antiviral properties, specifically inhibiting the cytotoxicity induced by SARS-CoV-2 in VERO-6 cells at a concentration of 10 µM after 48 hours, and inhibiting SARS-CoV-2 3CL-Pro protease and papain-like protease with respective IC50 values of 6680.0 nM. It also exhibits antiproliferative effects against human PC-3 and SW480 cells at 100 µM concentration, reducing cell growth by 13.0% and 12.0% respectively after 72 hours. Additional activities include a 26.0% antioxidant activity as a DPPH radical scavenger at 300 µM concentration and moderate antileishmanial activity against Leishmania donovani with an IC50 value of 20 µM, alongside showcasing limited antitrypanosomal activity indicated by IC50 values greater than 10000.0 nM and 15000.0 nM for Leishmania and Trypanosoma brucei brucei S16 respectively. Tyrosol’s diverse bioactivities make it a candidate for further studies in various therapeutic areas..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Tyrosol (2-(4-Hydroxyphenyl)ethanol) is a phenolic antioxidant that is naturally present in several foods such as wines and green tea and is present most abundantly in olives.
Synonyms	4-Hydroxyphenylethanol, 4-Hydroxyphenethyl alcohol, 2-(4-Hydroxyphenyl)ethanol

Chemical Properties

Molecular Weight	138.16
Formula	C₈H₁₀O₂
Cas No.	501-94-0
Smiles	OC1=CC=C(C=C1)CCO
Relative Density.	1.168 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 255 mg/mL (1845.69 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (14.48 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	7.2380 mL	36.1899 mL	72.3798 mL	361.8992 mL
5 mM	1.4476 mL	7.2380 mL	14.4760 mL	72.3798 mL
10 mM	0.7238 mL	3.6190 mL	7.2380 mL	36.1899 mL
20 mM	0.3619 mL	1.8095 mL	3.6190 mL	18.0950 mL
50 mM	0.1448 mL	0.7238 mL	1.4476 mL	7.2380 mL
100 mM	0.0724 mL	0.3619 mL	0.7238 mL	3.6190 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc