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G-418 disulfate

Name: G-418 disulfate
Brand: TargetMol
SKU: T6512
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6512Cas No. 108321-42-2

Alias Geneticin sulfate, Geneticin, G418 Sulfate, Antibiotic G-418 sulfate

G-418 disulfate (Geneticin sulfate) is an aminoglycoside antibiotic that selectively inhibits eukaryotic protein synthesis by blocking peptide chain elongation.

G-418 disulfate

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Purity: 99.9%

Catalog No. T6512Alias Geneticin sulfate, Geneticin, G418 Sulfate, Antibiotic G-418 sulfateCas No. 108321-42-2

G-418 disulfate (Geneticin sulfate) is an aminoglycoside antibiotic that selectively inhibits eukaryotic protein synthesis by blocking peptide chain elongation.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
200 mg	$30	In Stock	-

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.9%

Color:White

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	G-418 disulfate (Geneticin sulfate) is an aminoglycoside antibiotic that selectively inhibits eukaryotic protein synthesis by blocking peptide chain elongation.
Targets&IC50	BHK-21 cells:69 µg/mL, CHO-K1 cells:311 µg/mL, HeLa cells:483 µg/mL, 3T3 cells:213 µg/mL
In vitro	Continuous administration of G418 at doses ranging from 40 to 80 mg/kg for three consecutive days is sufficient to eradicate all untransfected Brucella bacterium parasites in infected mice.
In vivo	At concentrations ranging from 1 to 300 micrograms/ml, G418 inhibits a variety of prokaryotic and eukaryotic organisms. Typically, concentrations of 5 mg/L or lower are effective against bacteria and algae, while a concentration of 400 mg/L is used for the selection of mammalian cells, and a maintenance concentration for mammalian cells is set at 200 mg/L.
Synonyms	Geneticin sulfate, Geneticin, G418 Sulfate, Antibiotic G-418 sulfate

Chemical Properties

Molecular Weight	692.71
Formula	C₂₀H₄₀N₄O₁₀·2H₂O₄S
Cas No.	108321-42-2
Smiles	OS(O)(=O)=O.OS(O)(=O)=O.CN[C@@H]1[C@@H](O)[C@@H](O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3O[C@H]([C@@H](C)O)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)OC[C@]1(C)O
Relative Density.	no data available

Storage & Solubility Information

Storage

store under nitrogen | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 252 mg/mL (363.79 mM), Sonication is recommended.

DMSO: Insoluble

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	1.4436 mL	7.2180 mL	14.4361 mL	72.1803 mL
5 mM	0.2887 mL	1.4436 mL	2.8872 mL	14.4361 mL
10 mM	0.1444 mL	0.7218 mL	1.4436 mL	7.2180 mL
20 mM	0.0722 mL	0.3609 mL	0.7218 mL	3.6090 mL
50 mM	0.0289 mL	0.1444 mL	0.2887 mL	1.4436 mL
100 mM	0.0144 mL	0.0722 mL	0.1444 mL	0.7218 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc