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G-418 disulfate

G-418 disulfate
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Purity:99.9%
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G-418 disulfate

Catalog No. T6512Cas No. 108321-42-2
G-418 disulfate (Geneticin sulfate) is an aminoglycoside antibiotic, an inhibitor of protein synthesis with eukaryotic selectivity. G-418 disulfate blocks peptide synthesis by inhibiting peptide chain elongation.
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Pack SizePriceAvailabilityQuantity
500 mg$33.6$42In Stock
1 g$40$50In Stock
5 g$126.4$158In Stock
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Product Introduction

Bioactivity
Description
G-418 disulfate (Geneticin sulfate) is an aminoglycoside antibiotic, an inhibitor of protein synthesis with eukaryotic selectivity. G-418 disulfate blocks peptide synthesis by inhibiting peptide chain elongation.
In vitro
Continuous administration of G418 at doses ranging from 40 to 80 mg/kg for three consecutive days is sufficient to eradicate all untransfected Brucella bacterium parasites in infected mice.
In vivo
At concentrations ranging from 1 to 300 micrograms/ml, G418 inhibits a variety of prokaryotic and eukaryotic organisms. Typically, concentrations of 5 mg/L or lower are effective against bacteria and algae, while a concentration of 400 mg/L is used for the selection of mammalian cells, and a maintenance concentration for mammalian cells is set at 200 mg/L.
AliasGeneticin, G418 Sulfate, Antibiotic G-418 sulfate, Geneticin sulfate
Chemical Properties
Molecular Weight692.71
FormulaC20H40N4O10·2H2O4S
Cas No.108321-42-2
Storage & Solubility Information
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
H2O: 43.31mM
DMSO: Insoluble
Solution Preparation Table
H2O
1mg5mg10mg50mg
50 mM0.0289 mL0.1444 mL0.2887 mL1.4436 mL
100 mM0.0144 mL0.0722 mL0.1444 mL0.7218 mL

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