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GNE-0946

Name: GNE-0946
Brand: TargetMol
SKU: T15398
Price: 199 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15398Cas No. 1677667-24-1

Alias GNE 0946

GNE-0946 is an effective and selective RORγ/RORc/NR1F3 antagonist (inverse agonist) with an EC50 of 4 nM in HEK-293 cells. It inhibits IL-17 production in human PBMC cells (IC50 = 17 nM) and can be used in autoimmune disease research.

GNE-0946

😃Good

Purity: 98.11%

Catalog No. T15398Alias GNE 0946Cas No. 1677667-24-1

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$199	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:98.11%

Resource Download

COA MS HNMR HPLC

Product Introduction

Bioactivity

Description	GNE-0946 is an effective and selective RORγ/RORc/NR1F3 antagonist (inverse agonist) with an EC50 of 4 nM in HEK-293 cells. It inhibits IL-17 production in human PBMC cells (IC50 = 17 nM) and can be used in autoimmune disease research.
Synonyms	GNE 0946

Chemical Properties

Molecular Weight	460.79
Formula	C₂₂H₁₂ClF₃N₂O₄
Cas No.	1677667-24-1
Smiles	O=C(O)C=1C=CC(=CC1O)C=2N=C(C(=O)C=3C(Cl)=CC=CC3C(F)(F)F)N4C=CC=CC24
Relative Density.	1.53 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (173.61 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1702 mL	10.8509 mL	21.7019 mL	108.5093 mL
5 mM	0.4340 mL	2.1702 mL	4.3404 mL	21.7019 mL
10 mM	0.2170 mL	1.0851 mL	2.1702 mL	10.8509 mL
20 mM	0.1085 mL	0.5425 mL	1.0851 mL	5.4255 mL
50 mM	0.0434 mL	0.2170 mL	0.4340 mL	2.1702 mL
100 mM	0.0217 mL	0.1085 mL	0.2170 mL	1.0851 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc