Shopping Cart

Your shopping cart is currently empty

7-Hydroxyflavanone

Name: 7-Hydroxyflavanone
Brand: TargetMol
SKU: T7999
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T7999Cas No. 6515-36-2

7-Hydroxyflavanone shows antimicrobial activity against Streptococcus pneumoniae clinical isolates.

7-Hydroxyflavanone

Copy Product Info

😃Good

Purity: 99.81%

Catalog No. T7999Cas No. 6515-36-2

7-Hydroxyflavanone shows antimicrobial activity against Streptococcus pneumoniae clinical isolates.

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$40	-	In Stock
200 mg	$56	-	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.81%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HNMR HPLC

Product Introduction

7-Hydroxyflavanone AI Summary

7-Hydroxyflavanone exhibits a broad range of bioactivities across various biological systems. It inhibits hamster liver mitochondrial monoamine oxidase (MAO) with an IC50 value of 13000.0 nM and demonstrates significant potency as an aromatase inhibitor in human placental microsomes, with an IC50 value of 3800.0 nM. Additionally, it shows relative activity against aminogluthetimide with a relative activity of 1.4. In bovine thymocytes, 7-Hydroxyflavanone inhibits protein tyrosine kinase with an ID50 value greater than 500.0 ug/mL. It also increases EGR1 mRNA expression in human HEK293 cells at 20 ug/mL after 6 to 12 hours, achieving a fold change of 2.1. The compound displays binding affinity to Enterococcus faecalis KAS3, with an activity value of 8.79 x 10^2/M, indicating a potential interaction with this target protein. Moreover, 7-Hydroxyflavanone is noted for various other bioactivities, including modulation of mitochondrial dynamics, miRNA regulation (specifically miR-21), re-activation of p53, inhibition of malaria parasite plastid delayed death, inverse agonism of the GLP-1 receptor, and activation of BRCA1 expression. Furthermore, it possesses antifungal properties, showing moderate antifungal potency against different fungal isolates, with a notably strong activity against Diaporthe longicolla isolate CE117, where it has a MIC value of 6.25 ug/mL..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

7-Hydroxyflavanone shows antimicrobial activity against Streptococcus pneumoniae clinical isolates.

Chemical Properties

Molecular Weight	240.25
Formula	C₁₅H₁₂O₃
Cas No.	6515-36-2
Smiles	Oc1ccc2C(=O)CC(Oc2c1)c1ccccc1
Relative Density.	1.288g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (104.06 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.1623 mL	20.8117 mL	41.6233 mL	208.1165 mL
5 mM	0.8325 mL	4.1623 mL	8.3247 mL	41.6233 mL
10 mM	0.4162 mL	2.0812 mL	4.1623 mL	20.8117 mL
20 mM	0.2081 mL	1.0406 mL	2.0812 mL	10.4058 mL
50 mM	0.0832 mL	0.4162 mL	0.8325 mL	4.1623 mL
100 mM	0.0416 mL	0.2081 mL	0.4162 mL	2.0812 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc