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Anti-Fas/CD95 Antibody (4A58)
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Catalog No. TMAC-01446
Alias TNFRSF6, FASTM, FAS1, Fas cell surface death receptor, CD95, APT1, APO-1, ALPS1A
Anti-Fas/CD95 Antibody (4A58) is a Rabbit antibody targeting Fas/CD95. Anti-Fas/CD95 Antibody (4A58) can be used in WB,ICC/IF,IHC,FCM.
Anti-Fas/CD95 Antibody (4A58)
Anti-Fas/CD95 Antibody (4A58)
😃Good
Catalog No. TMAC-01446Alias TNFRSF6, FASTM, FAS1, Fas cell surface death receptor, CD95, APT1, APO-1, ALPS1A
Anti-Fas/CD95 Antibody (4A58) is a Rabbit antibody targeting Fas/CD95. Anti-Fas/CD95 Antibody (4A58) can be used in WB,ICC/IF,IHC,FCM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $297 | 7-10 days | |
| 100 μL | $498 | 7-10 days |
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Chemical Properties
| Description | Anti-Fas/CD95 Antibody (4A58) is a Rabbit antibody targeting Fas/CD95. Anti-Fas/CD95 Antibody (4A58) can be used in WB,ICC/IF,IHC,FCM. |
| Synonyms | TNFRSF6, FASTM, FAS1, Fas cell surface death receptor, CD95, APT1, APO-1, ALPS1A |
| Ig Type | IgG |
| Reactivity | Human |
| Verified Activity | 1. Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-Fas antibody. Counter stained with hematoxylin. 2. Immunohistochemical analysis of paraffin-embedded human liver cancer tissue using anti-Fas antibody. Counter stained with hematoxylin. 3. ICC staining Fas in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 4. ICC staining Fas in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 5. Flow cytometric analysis of Raji cells with Fas antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody. |
| Application | |
| Recommended Dose | WB: 1:500-1000; IHC: 1:50-200; ICC/IF: 1:50-200; FCM: 1:50-100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | Cytotoxic T lymphocyte (CTL)-mediated cytotoxicity constitutes an important component of specific effector mechanisms in immuno-surveillance against virus-infected or transformed cells. Two mechanisms appear to account for this activity, one of which is the perforin-based process. Independently, a FAS-based mechanism involves the transducing molecule FAS (also designated APO-1) and its ligand (FAS-L). The human FAS protein is a cell surface glycoprotein that belongs to a family of receptors that includes CD40, nerve growth factor receptors and tumor necrosis factor receptors. The FAS antigen is expressed on a broad range of lymphoid cell lines, certain of which undergo apoptosis in response to treatment with antibody to FAS. These findings strongly imply that targeted cell death is potentially mediated by the intercellular interactions of FAS with its ligand or effectors, and that FAS may be critically involved in CTL-mediated cytotoxicity. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein |
| Uniprot ID |
| Molecular Weight | Theoretical: 45 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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