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AKR1B1 Protein, Human, Recombinant (His)
(Synonyms: MGC1804, AR, ALR2, ALDR1, aldo-keto reductase family 1, member B1 (aldose reductase), ADR) Copy Product InfoSynonyms: MGC1804, AR, ALR2, ALDR1, aldo-keto reductase family 1, member B1 (aldose reductase), ADR
Catalog No. TMPY-02438 Copy Product Info
Aldose reductase (AKR1B1) belongs to the aldo/keto reductase superfamily. AKR1B1 is a NADPH-dependent aldo-keto reductase best known as the rate-limiting enzyme of the polyol pathway. Expression of AKR1B1 was the highest in lens and retina. It is the first enzyme in the polyol pathway through which glucose is converted to sorbitol which is important for the function of various organs in the body, and has been implicated in the etiology of diabetic complications. AKR1B1 is quite abundant in the collecting tubule cells and thought to provide protection against hypertonic environment. Some human tissues contain AKR1B1 as well as AKR1B10, a closely related member of the aldo-keto reductase superfamily.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 μg | $98 | 7-10 days | 7-10 days | |
| 10 μg | $158 | 7-10 days | 7-10 days | |
| 20 μg | $266 | 7-10 days | 7-10 days | |
| 50 μg | $525 | 7-10 days | 7-10 days | |
| 100 μg | $886 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:≥ 90 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC.
Appearance:Liquid
Color:Transparent
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first. |
| Description | Aldose reductase (AKR1B1) belongs to the aldo/keto reductase superfamily. AKR1B1 is a NADPH-dependent aldo-keto reductase best known as the rate-limiting enzyme of the polyol pathway. Expression of AKR1B1 was the highest in lens and retina. It is the first enzyme in the polyol pathway through which glucose is converted to sorbitol which is important for the function of various organs in the body, and has been implicated in the etiology of diabetic complications. AKR1B1 is quite abundant in the collecting tubule cells and thought to provide protection against hypertonic environment. Some human tissues contain AKR1B1 as well as AKR1B10, a closely related member of the aldo-keto reductase superfamily. |
| Species | Human |
| Expression System | E. coli |
| Tag | N-His |
| Accession Number | P15121 |
| Construction | A DNA sequence encoding the human AKR1B1 (P15121) (Met 1-Phe 316) was expressed, with a polyhistidine tag at the N-terminus. Predicted N terminal: Met |
| Protein Purity | > 90 % as determined by SDS-PAGE |
| Endotoxin | Please contact us for more information. |
| Formulation | Supplied as sterile PBS, 20% glycerol, pH 7.5. |
| Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
| Stability & Storage | It is recommended to store the product under sterile conditions at -20°C to -80°C. Samples are stable for up to 12 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | Proteins are shipped with blue ice. |
| Synonyms | MGC1804, AR, ALR2, ALDR1, aldo-keto reductase family 1, member B1 (aldose reductase), ADR |
| Research Background |
| Molecular Weight | 37.9 kDa (predicted); 36 kDa (reducing conditions) |
| Storage | Store at low temperature Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months |
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Related Tags: AKR1B1 Protein, Human, Recombinant (His) chemical structure | AKR1B1 Protein, Human, Recombinant (His) molecular weight
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