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4F-Docetaxel (Synonyms: 4F-DT, 4FDT, 4F DT)

Name: 4F-Docetaxel
Brand: TargetMol
SKU: TN9825
Rating: 4.5 (1 reviews)

Catalog No. TN9825 Copy Product Info

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4F-Docetaxel (4FDT) is a fluorinated derivative of docetaxel that exhibits significant antitumor activity against hepatocellular carcinoma (HCC) and is suitable for research on liver cancer.

4F-Docetaxel

Copy Product Info

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Catalog No. TN9825

Synonyms 4F-DT, 4FDT, 4F DT

4F-Docetaxel (4FDT) is a fluorinated derivative of docetaxel that exhibits significant antitumor activity against hepatocellular carcinoma (HCC) and is suitable for research on liver cancer.

Cas No. 912272-09-4

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

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Product Introduction

Bioactivity

Description	4F-Docetaxel (4FDT) is a fluorinated derivative of docetaxel that exhibits significant antitumor activity against hepatocellular carcinoma (HCC) and is suitable for research on liver cancer.
Targets&IC50	SKOV3 cells:3.4 x 10^-2 μM, HCT116 cells:0.1 x 10^-3 μM, CCD-18Co:17.13 μM, HEK293 cells:0.36 μM, SW-620:0.28 μM
In vitro	4F-Docetaxel exhibits cytotoxic effects against multiple tumor cell lines, with IC₅₀ values of 0.049 μM (95-D), 0.070 μM (SKOV3), 0.958 μM (HCT-116), 0.021 μM (HepG2), 0.022 μM (Bel-7402), 0.014 μM (SMMC-7721), 0.011 μM (SGC-7901), 0.043 μM (MDA-MB-231), 0.017 μM (A2780), 0.012 μM (KB), 0.006 μM (HL-60), 6.6 μM (U2OS)[1].
In vivo	In vivo studies, 4F-Docetaxel effectively reduced the proliferation rate of H22 and HepG2 liver cancer cells.Acute toxicity test showed that 4F-Docetaxel had fewer side effects (about 16% less than docetaxel) [1].
Synonyms	4F-DT, 4FDT, 4F DT

Chemical Properties

Molecular Weight	879.84
Formula	C₄₃H₄₉F₄NO₁₄
Cas No.	912272-09-4
Smiles	O(C(C)=O)[C@]12[C@]3([C@H](OC(=O)C4=CC(F)=CC=C4)[C@@]5(O)C(C)(C)C([C@@H](O)C(=O)[C@]3(C)[C@@H](O)C[C@]1(OC2)[H])=C(C)[C@@H](OC([C@@H]([C@@H](NC(OC(C(F)(F)F)(C)C)=O)C6=CC=CC=C6)O)=O)C5)[H]

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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You can also refer to dose conversion for different animals. More Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc