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Naratriptan hydrochloride

Name: Naratriptan hydrochloride
Brand: TargetMol
SKU: T6602
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6602Cas No. 143388-64-1

Alias Naratriptan HCl, Naramig, GR-85548A hydrochloride, Amerge

Naratriptan Hydrochloride is the hydrochloride salt form of naratriptan, a sulfonamide with selective serotonin (5-HT) 1 receptor agonistic activity and anti-migraine property. Naratriptan hydrochloride (GR-85548A hydrochloride) binds selectively and with high affinity to the 5-HT1D and 5-HT1B receptor subtypes. Activation of these 5-HT1D/B receptors located on intracranial blood vessels leads to vasoconstriction and provides relief of migraine headaches. Naratriptan hydrochloride may also exerts its effect by stimulation of 5-HT1D/1B receptors on sensory nerve endings in the trigeminal system thereby decreasing the release of pro-inflammatory neuropeptides.

Naratriptan hydrochloride

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Purity: 99.93%

Catalog No. T6602Alias Naratriptan HCl, Naramig, GR-85548A hydrochloride, AmergeCas No. 143388-64-1

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$48	In Stock	In Stock
50 mg	$81	-	In Stock
100 mg	$119	-	In Stock
500 mg	$295	-	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.93%

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description

Synonyms

Naratriptan HCl, Naramig, GR-85548A hydrochloride, Amerge

Chemical Properties

Molecular Weight	371.93
Formula	C₁₇H₂₅N₃O₂S·HCl
Cas No.	143388-64-1
Smiles	Cl.CNS(=O)(=O)CCc1ccc2[nH]cc(C3CCN(C)CC3)c2c1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 20 mg/mL (53.77 mM), Sonication is recommended.

DMSO: 65 mg/mL (174.76 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6887 mL	13.4434 mL	26.8868 mL	134.4339 mL
5 mM	0.5377 mL	2.6887 mL	5.3774 mL	26.8868 mL
10 mM	0.2689 mL	1.3443 mL	2.6887 mL	13.4434 mL
20 mM	0.1344 mL	0.6722 mL	1.3443 mL	6.7217 mL
50 mM	0.0538 mL	0.2689 mL	0.5377 mL	2.6887 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0269 mL	0.1344 mL	0.2689 mL	1.3443 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc