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TAK1/MAP4K2 inhibitor 1

Name: TAK1/MAP4K2 inhibitor 1
Brand: TargetMol
SKU: T10444
Rating: 4.5 (1 reviews)

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Catalog No. T10444Cas No. 1315330-11-0

TAK1/MAP4K2 inhibitor 1 (compound 5) is a dual kinase inhibitor of TAK1 and MAP4K2 with IC50 values of 41.1 nM and 18.2 nM, respectively.

TAK1/MAP4K2 inhibitor 1

😃Good

Catalog No. T10444Cas No. 1315330-11-0

TAK1/MAP4K2 inhibitor 1 (compound 5) is a dual kinase inhibitor of TAK1 and MAP4K2 with IC50 values of 41.1 nM and 18.2 nM, respectively.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$123	5 days	5 days
5 mg	$399	5 days	5 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Product Introduction

Bioactivity

Description	TAK1/MAP4K2 inhibitor 1 (compound 5) is a dual kinase inhibitor of TAK1 and MAP4K2 with IC50 values of 41.1 nM and 18.2 nM, respectively.
Targets&IC50	MAP4K2:18.2 nM, TAK1:41.1 nM
In vitro	TAK1/MAP4K2 inhibitor 1 is a highly potent dual inhibitor targeting both TGFβ-activated kinase 1 (TAK1) and MAP kinase kinase kinase kinase 2 (MAP4K2), with IC₅₀ values of 41.1 nM and 18.2 nM, respectively[1].
In vivo	TAK1/MAP4K2 inhibitor 1 (1 mg/kg, iv) has moderate terminal elimination half-life (t1/2=2.94 h) in mice.

Chemical Properties

Molecular Weight	552.59
Formula	C₂₉H₃₁F₃N₆O₂
Cas No.	1315330-11-0
Smiles	O=C(NC1=CC=C(C(=C1)C(F)(F)F)CN2CCN(CC)CC2)C3=CC=C(C(OC4=NC=NC=5NC(=CC45)C)=C3)C
Relative Density.	1.319 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (72.39 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.62 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8097 mL	9.0483 mL	18.0966 mL	90.4830 mL
5 mM	0.3619 mL	1.8097 mL	3.6193 mL	18.0966 mL
10 mM	0.1810 mL	0.9048 mL	1.8097 mL	9.0483 mL
20 mM	0.0905 mL	0.4524 mL	0.9048 mL	4.5241 mL
50 mM	0.0362 mL	0.1810 mL	0.3619 mL	1.8097 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc