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TAK1/MAP4K2 inhibitor 1

Name: TAK1/MAP4K2 inhibitor 1
Brand: TargetMol
SKU: T10444
Rating: 4.5 (1 reviews)

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Catalog No. T10444Cas No. 1315330-11-0

TAK1/MAP4K2 inhibitor 1 (compound 5) is a dual kinase inhibitor of TAK1 and MAP4K2 with IC50 values of 41.1 nM and 18.2 nM, respectively.

TAK1/MAP4K2 inhibitor 1

😃Good

Catalog No. T10444Cas No. 1315330-11-0

TAK1/MAP4K2 inhibitor 1 (compound 5) is a dual kinase inhibitor of TAK1 and MAP4K2 with IC50 values of 41.1 nM and 18.2 nM, respectively.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$123	5 days	5 days
5 mg	$399	5 days	5 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	TAK1/MAP4K2 inhibitor 1 (compound 5) is a dual kinase inhibitor of TAK1 and MAP4K2 with IC50 values of 41.1 nM and 18.2 nM, respectively.
Targets&IC50	TAK1:41.1 nM, MAP4K2:18.2 nM
In vitro	TAK1/MAP4K2 inhibitor 1 is a highly potent dual inhibitor targeting both TGFβ-activated kinase 1 (TAK1) and MAP kinase kinase kinase kinase 2 (MAP4K2), with IC₅₀ values of 41.1 nM and 18.2 nM, respectively[1].
In vivo	TAK1/MAP4K2 inhibitor 1 (1 mg/kg, iv) has moderate terminal elimination half-life (t1/2=2.94 h) in mice.

Chemical Properties

Molecular Weight	552.59
Formula	C₂₉H₃₁F₃N₆O₂
Cas No.	1315330-11-0
Smiles	O=C(NC1=CC=C(C(=C1)C(F)(F)F)CN2CCN(CC)CC2)C3=CC=C(C(OC4=NC=NC=5NC(=CC45)C)=C3)C
Relative Density.	1.319 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (72.39 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.62 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8097 mL	9.0483 mL	18.0966 mL	90.4830 mL
5 mM	0.3619 mL	1.8097 mL	3.6193 mL	18.0966 mL
10 mM	0.1810 mL	0.9048 mL	1.8097 mL	9.0483 mL
20 mM	0.0905 mL	0.4524 mL	0.9048 mL	4.5241 mL
50 mM	0.0362 mL	0.1810 mL	0.3619 mL	1.8097 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc