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TAK1/MAP4K2 inhibitor 1 (compound 5) is a dual kinase inhibitor of TAK1 and MAP4K2 with IC50 values of 41.1 nM and 18.2 nM, respectively.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $608 | In Stock | |
5 mg | $908 | 5 days | |
10 mg | $1,358 | 6-8 weeks | |
50 mg | $3,378 | 6-8 weeks | |
1 mL x 10 mM (in DMSO) | $1,089 | 5 days |
Description | TAK1/MAP4K2 inhibitor 1 (compound 5) is a dual kinase inhibitor of TAK1 and MAP4K2 with IC50 values of 41.1 nM and 18.2 nM, respectively. |
Targets&IC50 | MAP4K2:18.2 nM, TAK1:41.1 nM |
In vitro | TAK1/MAP4K2 inhibitor 1 is a highly potent dual inhibitor targeting both TGFβ-activated kinase 1 (TAK1) and MAP kinase kinase kinase kinase 2 (MAP4K2), with IC₅₀ values of 41.1 nM and 18.2 nM, respectively[1]. |
In vivo | TAK1/MAP4K2 inhibitor 1 (1 mg/kg, iv) has moderate terminal elimination half-life (t1/2=2.94 h) in mice. |
Molecular Weight | 552.59 |
Formula | C29H31F3N6O2 |
Cas No. | 1315330-11-0 |
Smiles | O=C(NC1=CC=C(C(=C1)C(F)(F)F)CN2CCN(CC)CC2)C3=CC=C(C(OC4=NC=NC=5NC(=CC45)C)=C3)C |
Relative Density. | 1.319 g/cm3 (Predicted) |
Storage | keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 40 mg/mL (72.39 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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