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Hesperidin (Cirantin) is a flavanone glycoside found in citrus fruits with antioxidant, anti-inflammatory, anti-carcinogenic, and antihypertensive and lipid-lowering activity.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
20 mg | $50 | In Stock | |
100 mg | $60 | In Stock | |
1 mL x 10 mM (in DMSO) | $50 | In Stock |
Description | Hesperidin (Cirantin) is a flavanone glycoside found in citrus fruits with antioxidant, anti-inflammatory, anti-carcinogenic, and antihypertensive and lipid-lowering activity. |
Targets&IC50 | Anti-hypertensive agent with lipid-lowering:116.68μmo/L |
In vitro | METHODS: Tumor cells HeLa and HT-29 were treated with Hesperidin (20-100 µM) for 24-72 h. Cell viability was measured by MTT assay. RESULTS: Treatment with Hesperidin significantly reduced cell viability and the effect of Hesperidin on cell viability was concentration and time dependent. Cells incubated with 100 µM Hesperidin for 72 h showed the greatest antiproliferative effect, with cell viability decreasing to 12% of control cells. [1] METHODS: Human mesothelioma cells MSTO-211H were treated with Hesperidin (40-160 µM) for 48 h. Apoptosis was detected using DAPI and PI staining. RESULTS: The percentage of sub-G1 phase increased from 20% to 35% in 40-160 µM Hesperidi-treated MSTO-211H cells. [2] |
In vivo | METHODS: To assay antitumor activity in vivo, Hesperidin (200 mg/kg) was administered by gavage to BALB/c mice bearing CT-26 xenografts once daily for five days. Hesperidin was then administered as a single dose of cyclophosphamide (25 mg/kg) for fourteen days. RESULTS: Leukocyte counts were increased in mice treated with Hesperidin prior to cyclophosphamide injection. This significant protective effect was observed 4 and 7 days after cyclophosphamide injection. In CT-26 tumor-bearing mice, co-administration of Hesperidin and cyclophosphamide significantly inhibited cyclophosphamide-induced delay in tumor growth. [3] |
Alias | Hesperetin 7-rutinoside, Cirantin |
Molecular Weight | 610.56 |
Formula | C28H34O15 |
Cas No. | 520-26-3 |
Smiles | O=C1C=2C(O[C@@H](C1)C3=CC(O)=C(OC)C=C3)=CC(O[C@@H]4O[C@H](CO[C@H]5[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O5)[C@@H](O)[C@H](O)[C@H]4O)=CC2O |
Relative Density. | 1.423 g/cm3. Temperature:20 °C. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 60 mg/mL (98.27 mM), Sonication is recommended. ![]() Ethanol: < 1 mg/mL (insoluble or slightly soluble) H2O: < 1 mg/mL (insoluble or slightly soluble) | ||||||||||||||||||||||||||||||
In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 6 mg/mL (9.83 mM), suspension.In vivo: Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.![]() | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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