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YS-49

🥰Excellent
Catalog No. T13376Cas No. 132836-42-1

YS-49 is an activator of PI3K/Akt (a downstream target of RhoA).

YS-49
Other Forms of YS-49:

YS-49

🥰Excellent
Purity: 99.65%
Catalog No. T13376Cas No. 132836-42-1
YS-49 is an activator of PI3K/Akt (a downstream target of RhoA).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$41In StockIn Stock
2 mg$56In StockIn Stock
5 mg$92In StockIn Stock
10 mg$147In StockIn Stock
25 mg$289In StockIn Stock
50 mg$429In StockIn Stock
100 mg$622In StockIn Stock
500 mg$1,280In StockIn Stock
1 mL x 10 mM (in DMSO)$98In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.65%
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COA HNMR LCMS HPLC

Product Introduction

Bioactivity
Description
YS-49 is an activator of PI3K/Akt (a downstream target of RhoA).
In vitro
In RAVSMC and RAW 264.7 cells, YS-49 (1-100?μM; 18 hours; ) concentration-dependently inhibits the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to lipopolysaccharide (LPS) plus INF-γ, with IC50 values of 22 μM and 30?μM, respectively[2].At the transcriptional level, YS-49 (10-100?μM; 18 hours; RAVSMC and RAW 264.7 cells) suppresses iNOS gene expression induced by LPS and/or cytokines in RAVSMC and RAW 264.7 cells [2].
In vivo
In male Sprague Dawley rats,YS-49 (5mg/kg; intraperitoneal injection; 8 hours) treatment significantly reduces serum NOx levels in LPS-treated rats, the NOx levels reduce from 86 μM to 34 μM[2].
Chemical Properties
Molecular Weight386.28
FormulaC20H20BrNO2
Cas No.132836-42-1
SmilesBr.Oc1cc2CCNC(Cc3cccc4ccccc34)c2cc1O
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 10 mg/mL (25.89 mM), Sonication and heating to 60℃ are recommended.
DMSO: 100 mg/mL (258.88 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (10.36 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM2.5888 mL12.9440 mL25.8880 mL129.4398 mL
5 mM0.5178 mL2.5888 mL5.1776 mL25.8880 mL
10 mM0.2589 mL1.2944 mL2.5888 mL12.9440 mL
20 mM0.1294 mL0.6472 mL1.2944 mL6.4720 mL
DMSO
1mg5mg10mg50mg
50 mM0.0518 mL0.2589 mL0.5178 mL2.5888 mL
100 mM0.0259 mL0.1294 mL0.2589 mL1.2944 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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%
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Keywords

β-adrenoceptorYS-49YS49YS 49Protein kinase BPKBPI3KPhosphoinositide 3-kinaseInhibitorinhibitBeta ReceptorAngiotensin ReceptorAktAdrenergicReceptorAdrenergic Receptor
Related Tags: buy YS-49 | purchase YS-49 | YS-49 cost | order YS-49 | YS-49 chemical structure | YS-49 in vivo | YS-49 in vitro | YS-49 formula | YS-49 molecular weight
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