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TNFR2/CD120b/TNFR1B Protein, Cynomolgus, Recombinant (His)
(Synonyms: TNFRSF1B, TNFR80, TNF-R75, TNF-R2, TNFR2, TNFR1B, TNFBR, TNF RII, TBPII, p75TNFR, p75TBPII, Etanercept, CD120b) Copy Product InfoSynonyms: TNFRSF1B, TNFR80, TNF-R75, TNF-R2, TNFR2, TNFR1B, TNFBR, TNF RII, TBPII, p75TNFR, p75TBPII, Etanercept, CD120b
Catalog No. TMPK-01382 Copy Product Info
Tumor Necrosis Factor Receptor II (TNF RII), also known as TNFRSF1B, p75/p80, and CD120b, is a type I transmembrane protein that belongs to the TNF receptor superfamily. It has a molecular weight of approximately 75 kDa.Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 µg | $46 | 7-10 days | 7-10 days | |
| 10 µg | $72 | 7-10 days | 7-10 days | |
| 20 µg | $115 | 7-10 days | 7-10 days | |
| 50 µg | $222 | 7-10 days | 7-10 days | |
| 100 µg | $371 | 7-10 days | 7-10 days | |
| 200 µg | $673 | 7-10 days | 7-10 days | |
| 500 µg | $1,490 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Immobilized Cynomolgus TNFR2, His Tag at 0.5μg/ml (100μl/Well) on the plate. Dose response curve for Anti-TNFR2 Antibody, hFc Tag with the EC50 of 3.5ng/ml determined by ELISA. |
| Description | Tumor Necrosis Factor Receptor II (TNF RII), also known as TNFRSF1B, p75/p80, and CD120b, is a type I transmembrane protein that belongs to the TNF receptor superfamily. It has a molecular weight of approximately 75 kDa.Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. |
| Species | Cynomolgus |
| Expression System | HEK293 Cells |
| Tag | C-His |
| Accession Number | A0A2K5VEV7 |
| Construction | Leu23-Asp257 |
| Protein Purity | > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS (pH 7.4). Typically, 8% trehalose is incorporated as a protective agent before lyophilization. |
| Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Synonyms | TNFRSF1B, TNFR80, TNF-R75, TNF-R2, TNFR2, TNFR1B, TNFBR, TNF RII, TBPII, p75TNFR, p75TBPII, Etanercept, CD120b |
| Research Background | Tumor Necrosis Factor Receptor II (TNF RII), also known as TNFRSF1B, p75/p80, and CD120b, is a type I transmembrane protein that belongs to the TNF receptor superfamily. It has a molecular weight of approximately 75 kDa.Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. |
| Molecular Weight | 26.1 kDa (predicted). Due to glycosylation, the protein migrates to 49-60 kDa based on Tris-Bis PAGE result. |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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Related Tags: TNFR2/CD120b/TNFR1B Protein, Cynomolgus, Recombinant (His) chemical structure | TNFR2/CD120b/TNFR1B Protein, Cynomolgus, Recombinant (His) molecular weight
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