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PI3Kδ-IN-15

Name: PI3Kδ-IN-15
Brand: TargetMol
SKU: T8651
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8651Cas No. 1146702-54-6

PI3Kδ-IN-15 is a selective PI3Kδ inhibitor that inhibits PI3Kδ more than 30-fold more effectively than PI3Kγ, PI3Kβ, and PI3Kα.

PI3Kδ-IN-15

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Purity: 99.61%

Catalog No. T8651Cas No. 1146702-54-6

PI3Kδ-IN-15 is a selective PI3Kδ inhibitor that inhibits PI3Kδ more than 30-fold more effectively than PI3Kγ, PI3Kβ, and PI3Kα.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$30	-	In Stock
10 mg	$43	-	In Stock
25 mg	$70	-	In Stock
50 mg	$89	-	In Stock
1 mL x 10 mM (in DMSO)	$48	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.61%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	PI3Kδ-IN-15 is a selective PI3Kδ inhibitor that inhibits PI3Kδ more than 30-fold more effectively than PI3Kγ, PI3Kβ, and PI3Kα.
Targets&IC50	p110γ (Cell-free assay):89 nM, hVps34:978 nM, p110α:820 nM, DNA-PK:6729 nM, p110δ (Cell-free assay):2.5 nM, p110β:565 nM
In vitro	PI3Kδ-IN-15 exhibited excellent efficiencies with sub-nanomolar functional potency when compared with the reference PI3Kδ inhibitor. PI3Kδ IC50 = 0.5 nM, PI3KγIC50 = 15.3 nM, PI3KβIC50 = 145 nM, and PI3KαIC50 = 152 nM. [1]

Chemical Properties

Molecular Weight	401.4
Formula	C₂₁H₁₆FN₇O
Cas No.	1146702-54-6
Smiles	[C@H](NC1=C2C(N=CN2)=NC=N1)(C)C=3N(C(=O)C=4C(N3)=CC=CC4F)C5=CC=CC=C5
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight,keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (62.28 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.98 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4913 mL	12.4564 mL	24.9128 mL	124.5640 mL
5 mM	0.4983 mL	2.4913 mL	4.9826 mL	24.9128 mL
10 mM	0.2491 mL	1.2456 mL	2.4913 mL	12.4564 mL
20 mM	0.1246 mL	0.6228 mL	1.2456 mL	6.2282 mL
50 mM	0.0498 mL	0.2491 mL	0.4983 mL	2.4913 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc