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Phenmedipham

Name: Phenmedipham
Brand: TargetMol
SKU: T20301
Rating: 4.5 (1 reviews)

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Catalog No. T20301Cas No. 13684-63-4

Alias Kemifam, HSDB 1402, Fenmedifam

Phenmedipham (Fenmedifam) is a herbicide commonly used in the growth of sugar beets and strawberries.

Phenmedipham

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Catalog No. T20301Alias Kemifam, HSDB 1402, FenmedifamCas No. 13684-63-4

Phenmedipham (Fenmedifam) is a herbicide commonly used in the growth of sugar beets and strawberries.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$29	4-6 weeks	4-6 weeks
25 mg	$46	4-6 weeks	4-6 weeks
50 mg	$68	4-6 weeks	4-6 weeks
100 mg	$98	4-6 weeks	4-6 weeks
200 mg	$129	4-6 weeks	4-6 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Phenmedipham AI Summary

Phenmedipham shows potent bioactivity with a high level of inhibition of human FAAH at 1 μM concentration (89.1% inhibition). It exhibits strong inhibitory effects on human FAAH with an IC50 value of 377.0 nM and on human FAAH-mediated hydrolysis of [3H]AEA with an IC50 value of 152.0 nM. Additionally, it significantly inhibits rat FAAH with an IC50 value of 77.0 nM, indicating its potential as a FAAH inhibitor for further research. The compound demonstrates low toxicity in rats with an LD50 value greater than 8000.0 mg/kg, suggesting a favorable safety profile. Beyond FAAH inhibition, Phenmedipham acts as an inhibitor of Aldehyde Dehydrogenase 1 (ALDH1A1), an activator of Cytochrome P450 3A4, and an agonist of the estrogen receptor alpha and androgen receptor signaling pathways. It also activates the Aryl hydrocarbon Receptor (AhR) signaling, disrupts mitochondrial membrane potential, and activates both rat and human pregnane X receptor (PXR) signaling pathways, showing agonistic activity towards the antioxidant response element (ARE) signaling pathway..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Phenmedipham (Fenmedifam) is a herbicide commonly used in the growth of sugar beets and strawberries.
Synonyms	Kemifam, HSDB 1402, Fenmedifam

Chemical Properties

Molecular Weight	300.31
Formula	C₁₆H₁₆N₂O₄
Cas No.	13684-63-4
Smiles	COC(=O)NC1=CC=CC(OC(=O)NC2=CC(C)=CC=C2)=C1
Relative Density.	1.1782 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (183.14 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3299 mL	16.6495 mL	33.2989 mL	166.4946 mL
5 mM	0.6660 mL	3.3299 mL	6.6598 mL	33.2989 mL
10 mM	0.3330 mL	1.6649 mL	3.3299 mL	16.6495 mL
20 mM	0.1665 mL	0.8325 mL	1.6649 mL	8.3247 mL
50 mM	0.0666 mL	0.3330 mL	0.6660 mL	3.3299 mL
100 mM	0.0333 mL	0.1665 mL	0.3330 mL	1.6649 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

PhenmediphamInhibitorinhibitHSDB-1402HSDB1402