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TargetMol | Compound Library

Anti-Alzheimer's Disease Compound Library

Catalog No. L9840

Alzheimer's disease (AD) is a progressive neurodegenerative disease with deficits in recent memory, wordfinding, and language difficulties, and gradually progresses to global cognitive impairment. The cognitive deficits are accompanied by a variety of abnormal neurological and psychiatric symptoms that increase in frequency and severity as the disease progresses. The cause of Alzheimer's disease is unknown but the fifth-leading cause of death among those age 65 and older. The pathological features of AD mainly include cholinergic dysfunction, extracellular accumulation and deposition of Aβ peptides, intracellular neurofibrillary tangles, and other aberrant signaling pathways. Scientists have found that reducing brain Aβ levels, preventing the excessive phosphorylation of tau protein, rendering mitochondria resistant to damage, protecting neurons from apoptotic processes, controlling microglial activation, inhibiting the release of interleukin-2 and TNF-α, preventing oxidative stress damage; regulating the targets in cholinergic system, inhibiting the over activation of NMDA receptor to reduce the excitotoxicity can halt Alzheimer's disease.  Although Alzheimer's disease (AD) is the world's leading cause of dementia and the population of patients with AD continues to grow, no new therapies have been approved in more than a decade. Over the past decade, the focus of drug discovery and development efforts has shifted from symptom improving toward disease-modifying therapies for AD; that is, treatments whose aim is to affect the underlying disease process by impacting one or more of the many brain changes characteristic of AD. Many clinical trials of single-agent therapies have failed to affect disease progression or symptoms compared with placebo. The complex pathophysiology of AD may necessitate combination treatments rather than monotherapy. In addition, small molecules targeting neural stem cells (NSCs) regeneration represents a new drug discovery strategy. TargetMol's Anti-Alzheimer's Disease Compound Library, a collection of 1881 compounds with anti-AD activities or acting on main drug targets of AD, can be used for related drug discovery and pharmacology research.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L9840

Anti-Alzheimer's Disease Compound Library

sizeIn stock

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Description Product Description

  • A unique collection of 1881 compounds with anti-AD activities or acting on main drug targets of AD can be used for HTS and HCS.
  • Targets include tau protein, γ Secretase, 5-HT Receptor, BACE, etc.
  • Some of them are FDA approved.?
  • Structurally diverse, medicinally active, and cell permeable;
  • Detailed information about compound structure, target, activity, IC50, etc.
  • NMR and HPLC/LCMS validated to ensure high purity and quality.

Packaging And Storage | TargetMol Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice

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Compound Library | TargetMol
Targetmol Compound Libraries
can be highly customized!
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Library Customization | TargetMol Library Composition

5-HT Receptor
AChR
Dopamine Receptor
PPAR
Wnt/beta-catenin
TNF
Cholinesterase (ChE)
Apoptosis
Autophagy
GSK-3
AMPK
Histamine Receptor
Adrenergic Receptor
TLR
Beta Amyloid
Endogenous Metabolite
NF-κB
Antibacterial
GABA Receptor
Gamma-secretase
IL Receptor
COX
Norepinephrine
Serotonin Transporter
CDK
MAO
NOD
Parasite
Calcium Channel
BACE
Potassium Channel
Cytochromes P450
Sodium Channel
Akt
Antioxidant
Reactive Oxygen Species
Interleukin
Influenza Virus
Antibiotic
NO Synthase
PARP
p38 MAPK
Beta-Secretase
ERK
HIV Protease
iGluR
Microtubule Associated
PDE
Monoamine Oxidase
Prostaglandin Receptor
TRP/TRPV Channel
Ferroptosis
GluR
NOD-like Receptor (NLR)
Src
STAT
Virus Protease
Antifungal
JNK
MAPK
MMP
Transferase
Tyrosinase
Bcl-2 Family
Caspase
Drug Metabolite
EGFR
Mitochondrial Metabolism
NOS
P-gp
Sigma receptor
transporter
CaMK
Dehydrogenase
JAK
Lipoxygenase
NMDAR
Nrf2
PI3K
PKA
SARS-CoV
VEGFR
ABC Transporter
Antiviral
Cannabinoid Receptor
Casein Kinase
FGFR
FLT
HCV Protease
Mitophagy
mTOR
Phospholipase
ROS
Antifection
Aurora Kinase
Bcr-Abl
DNA/RNA Synthesis
Epigenetic Reader Domain
Fatty Acid Synthase
GPR
HER
Immunology/Inflammation related
IκB/IKK
Ligand for E3 Ligase
Molecular Glues
Opioid Receptor
P2X Receptor
PDGFR
Phosphatase
PKC
Porcupine
S6 Kinase
Adenylyl Cyclase
Anti-infection
Chloride channel
DYRK
Glucosidase
HBV
HDAC
HIF/HIF Prolyl-Hydroxylase
HSV
IGF-1R
MEK
Melatonin Receptor
RAAS
Sirtuin
TGF-beta/Smad
Acyltransferase
Adenosine Receptor
Advanced Glycation End Products
AIM2
ATM/ATR
cAMP
Carbonic Anhydrase
CCR
c-Fms
Chk
c-Kit
Cysteine Protease
E1/E2/E3 Enzyme
Estrogen/progestogen Receptor
Glucocorticoid Receptor
GlyT
Histone Methyltransferase
LDL
Leukotriene Receptor
Lipid
Monoamine Transporter
MRP
MT Receptor
MyD88
p53
PAFR
Retinoid Receptor
Topoisomerase
Trk receptor
FOXO3
ACK1
Amino Acids and Derivatives
Aminopeptidase
Amylase
Androgen Receptor
Annexin A
Arginase
Aromatase
Arrestin
Aryl Hydrocarbon Receptor
ATP Citrate Lyase
Bombesin Receptor
CFTR
Cholecystokinin Receptor
c-Myc
c-RET
CSF-1R
DHFR
DNA
DNA Methyltransferase
Dynamin
Epoxide Hydrolase
Estrogen Receptor/ERR
FAK
FLAP
FXR
GluCls
Glucokinase
Glutaminyl Cyclase
gp120/CD4
GRK
GST
GTPase
Hck
HIF
Histone Demethylase
Huntingtin
Hydroxylase
IFNAR
Indoleamine 2,3-Dioxygenase (IDO)
Integrin
LTR
Melanin-concentrating Hormone Receptor (MCHR)
Methionine Adenosyltransferase (MAT)
NADPH-oxidase
NPC1L1
OCT
PAI-1
PDK
PERK
PGE Synthase
Piezo Channel
PKM
PLK
PROTACs
Proteasome
PTEN
Raf
Reverse Transcriptase
RSV
Serine Protease
Serine/threonin kinase
SIK
Somatostatin
Stearoyl-CoA Desaturase (SCD)
Telomerase
Thrombin
Tie-2
Transaminase
Tyrosine Kinases
YAP
ADC Cytotoxin
BTK

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