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Gatipotuzumab
(Synonyms: PankoMab) Copy Product Info
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Synonyms: PankoMab
Catalog No. T78318 Copy Product Info
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Gatipotuzumab (PankoMab) is a novel humanized monoclonal antibody conjugated to the tumor-associated epitope of mucin 1 (TA-MUC1) with potential anti-tumor activity for the study of recurrent epithelial ovarian cancer.
Cas No. 1264737-26-9
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $277 | - | In Stock | |
| 5 mg | $722 | Inquiry | Inquiry | |
| 10 mg | $1,150 | Inquiry | Inquiry | |
| 25 mg | $1,690 | Inquiry | Inquiry | |
| 50 mg | $2,290 | Inquiry | Inquiry | |
| 100 mg | $3,120 | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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Purity:98.6% (SDS-PAGE); 99.2% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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Chemical Properties
Antibody Information
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| Description | Gatipotuzumab (PankoMab) is a novel humanized monoclonal antibody conjugated to the tumor-associated epitope of mucin 1 (TA-MUC1) with potential anti-tumor activity for the study of recurrent epithelial ovarian cancer. |
| Targets & IC50 | MCF-7 cells:3.84 nM (KD), NM-D4 cells:0.91 nM (KD), T47D cells:7.14 nM (KD), ZR751 cells:3.03 nM (KD) |
| In vitro | Gatipotuzumab can effectively bind to a short MUC1 peptide consisting of 30 amino acids and containing 1.5 TRs. When this peptide is glycosylated with GalNAcα at the T position of the PDTRP sequence, it forms a strong bond; however, no binding occurs when the peptide is not glycosylated. Within 1 hour of treatment, Gatipotuzumab demonstrates high affinity for tumor cells, with KD values of 0.91, 3.03, 3.84, and 7.14 nM for NM-D4, ZR75-1, MCF-7, and T-47D, respectively. After 4 hours of treatment at concentrations ranging from 0 to 5 μg/mL, Gatipotuzumab exhibits specific antibody-dependent cytotoxic activity against tumors. [2] |
| Synonyms | PankoMab |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | MUC1 |
| Molecular Weight | 146.54 kDa |
| Cas No. | 1264737-26-9 |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | Store at low temperature -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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Related Tags: Gatipotuzumab chemical structure | Gatipotuzumab in vitro | Gatipotuzumab molecular weight
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