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Meleagrin

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Catalog No. T16035Cas No. 71751-77-4

Meleagrin, a roquefortine C-derived alkaloid produced by Penicillium fungi, serves as both a class of FabI inhibitors and a lead c-Met inhibitory entity for controlling c-Met-dependent metastatic and invasive breast malignancies. It exhibits antimicrobial and anti-proliferative activities.

Meleagrin

Meleagrin

😃Good
Catalog No. T16035Cas No. 71751-77-4
Meleagrin, a roquefortine C-derived alkaloid produced by Penicillium fungi, serves as both a class of FabI inhibitors and a lead c-Met inhibitory entity for controlling c-Met-dependent metastatic and invasive breast malignancies. It exhibits antimicrobial and anti-proliferative activities.
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5 mg$1,42035 days
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Product Introduction

Bioactivity
Description
Meleagrin, a roquefortine C-derived alkaloid produced by Penicillium fungi, serves as both a class of FabI inhibitors and a lead c-Met inhibitory entity for controlling c-Met-dependent metastatic and invasive breast malignancies. It exhibits antimicrobial and anti-proliferative activities.
In vitro
Meleagrin induces a dose-dependent inhibition of HGF-induced cell migration, and invasion of breast cancer cell lines. Meleagrin suppresses the growth of the human breast cancer cell lines MDA-MB-231, MDA-468, BT-474, SK BR-3, MCF7 and MCF7-dox [3].
In vivo
In an orthotopic athymic nude mice model, Meleagrin effectively inhibits the invasive triple-negative breast tumor cell growth[3].
Chemical Properties
Molecular Weight433.46
FormulaC23H23N5O4
Cas No.71751-77-4
Relative Density.1.47g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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Meleagrin
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