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RO6889678

Name: RO6889678
Brand: TargetMol
SKU: T9054
Price: 68 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T9054Cas No. 1578153-27-1

RO6889678 is HBV inhibitor with a complex ADME profile.

RO6889678

🥰Excellent

Purity: 98.72%

Catalog No. T9054Cas No. 1578153-27-1

RO6889678 is HBV inhibitor with a complex ADME profile.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$68	In Stock	In Stock
2 mg	$98	In Stock	In Stock
5 mg	$138	In Stock	In Stock
10 mg	$198	In Stock	In Stock
25 mg	$283	In Stock	In Stock
50 mg	$452	In Stock	In Stock
100 mg	$665	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$169	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:98.72%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS HPLC

Product Introduction

Bioactivity

Description

RO6889678 is HBV inhibitor with a complex ADME profile.

In vitro

RO6889678, a novel inhibitor of HBV with a complex absorption, distribution, metabolism, and excretion (ADME) profile.?RO6889678 showed an intracellular enrichment of 78-fold in hepatocytes, with an apparent intrinsic clearance of 5.2 l/min per mg protein and uptake and biliary clearances of 2.6 and 1.6 l/min per mg protein, respectively.?When apparent intrinsic clearance was incorporated into a PBPK model, the simulated oral human profiles were in good agreement with observed data at low doses but were underestimated at high doses due to unexpected overproportional increases in exposure with dose.?In addition, the induction potential of RO6889678 on cytochrome P450 (P450) enzymes and transporters at steady state was assessed and cotreatment with ritonavir revealed a complex drug-drug interaction with concurrent P450 inhibition and moderate UDP-glucuronosyltransferase induction.

Chemical Properties

Molecular Weight	494.92
Formula	C₂₁H₂₀ClFN₄O₅S
Cas No.	1578153-27-1
Smiles	COC(=O)C1=C(NC(=N[C@H]1C2=C(C=C(C=C2)F)Cl)C3=NC=CS3)CN4CCOC[C@H]4C(=O)O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (111.13 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0205 mL	10.1026 mL	20.2053 mL	101.0264 mL
5 mM	0.4041 mL	2.0205 mL	4.0411 mL	20.2053 mL
10 mM	0.2021 mL	1.0103 mL	2.0205 mL	10.1026 mL
20 mM	0.1010 mL	0.5051 mL	1.0103 mL	5.0513 mL
50 mM	0.0404 mL	0.2021 mL	0.4041 mL	2.0205 mL
100 mM	0.0202 mL	0.1010 mL	0.2021 mL	1.0103 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc