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7,4'-Dihydroxyflavone

🥰Excellent
Catalog No. TN1273Cas No. 2196-14-7
Alias 4',7-Dihydroxyflavone

7,4'-Dihydroxyflavone (4',7-Dihydroxyflavone) can induce transcription of nodulation (nod) genes in Rhizobium meliloti. It has inhibitory activities against COX-2.

7,4'-Dihydroxyflavone

7,4'-Dihydroxyflavone

🥰Excellent
Purity: 99.6%
Catalog No. TN1273Alias 4',7-DihydroxyflavoneCas No. 2196-14-7
7,4'-Dihydroxyflavone (4',7-Dihydroxyflavone) can induce transcription of nodulation (nod) genes in Rhizobium meliloti. It has inhibitory activities against COX-2.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$30In StockIn Stock
1 mL x 10 mM (in DMSO)$32In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.6%
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Product Introduction

Bioactivity
Description
7,4'-Dihydroxyflavone (4',7-Dihydroxyflavone) can induce transcription of nodulation (nod) genes in Rhizobium meliloti. It has inhibitory activities against COX-2.
Targets&IC50
NCI-H292 cells:1.4 μM (NCI-H292 human airway epithelial cell) (IC50)
In vitro
Root exudate from 3-day-old alfalfa seedlings was purified and then assayed for biological activity with a nodABC-lacZ fusion in R. meliloti. Indentities of major nod inducers were established by spectroscopic analyses (ultraviolet/visible, proton nuclear magnetic resonance, and mass spectroscopy) and comparison with authentic standards. Major nod inducers, which were identified as 4',7-Dihydroxyflavone, 4'-7-dihydroxyflavanone, and 4,4'-dihydroxy-2'-methoxychalcone, were released from seedling roots at 54, 22, and 20 picomole.plant(-1).day(-1), respectively. Luteolin was not found in these root exudates.
Synonyms4',7-Dihydroxyflavone
Chemical Properties
Molecular Weight254.24
FormulaC15H10O4
Cas No.2196-14-7
SmilesOc1ccc(cc1)-c1cc(=O)c2ccc(O)cc2o1
Relative Density.1.443 g/cm3
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 250 mg/mL (983.32 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (19.67 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.9333 mL19.6665 mL39.3329 mL196.6646 mL
5 mM0.7867 mL3.9333 mL7.8666 mL39.3329 mL
10 mM0.3933 mL1.9666 mL3.9333 mL19.6665 mL
20 mM0.1967 mL0.9833 mL1.9666 mL9.8332 mL
50 mM0.0787 mL0.3933 mL0.7867 mL3.9333 mL
100 mM0.0393 mL0.1967 mL0.3933 mL1.9666 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

Nuclear factor-κBNuclear factor-kappaBNOD1NF-κBNFκBNF-kBNFkBInhibitorinhibitHDAC2COXCCRCC chemokine receptor7,4'-Dihydroxyflavone7,4'Dihydroxyflavone7,4' Dihydroxyflavone
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