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H2L5186303

Name: H2L5186303
Brand: TargetMol
SKU: T22835
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22835Cas No. 139262-76-3

Alias ZINC33388081

H2L5186303 is an LPA2 antagonist and can be used in studies about asthma treatment.

H2L5186303

🥰Excellent

Purity: 98.19%

Catalog No. T22835Alias ZINC33388081Cas No. 139262-76-3

H2L5186303 is an LPA2 antagonist and can be used in studies about asthma treatment.

Pack Size	Price	Availability
2 mg	$37	In Stock
5 mg	$58	In Stock
10 mg	$95	In Stock
25 mg	$189	In Stock
50 mg	$297	In Stock
100 mg	$489	In Stock
200 mg	$675	In Stock
1 mL x 10 mM (in DMSO)	$69	In Stock

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Purity:98.19%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	H2L5186303 is an LPA2 antagonist and can be used in studies about asthma treatment.
Targets&IC50	LPA2 receptor:9 nM (IC50)
In vitro	The high cell invasion activity of HT1080-M6 cells is significantly suppressed by H2L5186303[1].
In vivo	H2L5186303 shows strong suppressive efficacy when administered before OVA sensitization and challenge, such as suppression of airway hyper responsiveness, inflammatory cytokine levels, mucin production, and eosinophil numbers[2].
Synonyms	ZINC33388081

Chemical Properties

Molecular Weight	488.45
Formula	C₂₆H₂₀N₂O₈
Cas No.	139262-76-3
Smiles	OC(=O)\C=C/C(=O)Nc1ccc(Oc2cccc(Oc3ccc(NC(=O)\C=C/C(O)=O)cc3)c2)cc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (409.5 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0473 mL	10.2365 mL	20.4729 mL	102.3646 mL
5 mM	0.4095 mL	2.0473 mL	4.0946 mL	20.4729 mL
10 mM	0.2047 mL	1.0236 mL	2.0473 mL	10.2365 mL
20 mM	0.1024 mL	0.5118 mL	1.0236 mL	5.1182 mL
50 mM	0.0409 mL	0.2047 mL	0.4095 mL	2.0473 mL
100 mM	0.0205 mL	0.1024 mL	0.2047 mL	1.0236 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc