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A 77636 hydrochloride

Catalog No. T21782 CAS 145307-34-2

Synonyms: A77636 hydrochloride

A 77636 hydrochloride is a potent, orally active, selective and long acting dopamine D1 receptor agonist (pKi=7.40; Ki=39.8 nM). A 77636 hydrochloride shows antiparkinsonian activity. A 77636 hydrochloride is functionally inactive at dopamine D2 receptor.

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A 77636 hydrochloride Chemical Structure

A 77636 hydrochloride, CAS 145307-34-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 97.00
5 mg	In stock	$ 228.00
10 mg	In stock	$ 333.00
25 mg	In stock	$ 561.00
50 mg	In stock	$ 789.00
1 mL * 10 mM (in DMSO)	In stock	$ 238.00

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Purity: 99.62%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	A 77636 hydrochloride is a potent, orally active, selective and long acting dopamine D1 receptor agonist (pKi=7.40; Ki=39.8 nM). A 77636 hydrochloride shows antiparkinsonian activity. A 77636 hydrochloride is functionally inactive at dopamine D2 receptor.
In vivo	A-77636 (0.1-1 mg/kg) exerts a suppressant effect on food intake in male hooded rat, due principally to a reduction in meal size and duration[3].

Synonyms	A77636 hydrochloride
Molecular Weight	365.89
Formula	C20H28ClNO3
CAS No.	145307-34-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 3.66 mg/mL (10 mM)

H2O: soluble

References and Literature

1. Kebabian JW, et al. A-77636: a potent and selective dopamine D1 receptor agonist with antiparkinsonian activity in marmosets. Eur J Pharmacol. 1992;229(2-3):203-209. 2. Smith LA, et al. The actions of a D-1 agonist in MPTP treated primates show dependence on both D-1 and D-2 receptor function and tolerance on repeated administration. J Neural Transm (Vienna). 2002;109(2):123-140. 3. Cooper SJ, et al. The anorectic effect of the selective dopamine D1-receptor agonist A-77636 determined by meal pattern analysis in free-feeding rats. Eur J Pharmacol. 2006;532(3):253-257.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Membrane Protein-targeted Compound Library GPCR Compound Library Bioactive Compounds Library Max Neurotransmitter Receptor Compound Library Neuronal Signaling Compound Library Antidepressant Compound Library Orally Active Compound Library Bioactive Compound Library

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Keywords

A 77636 hydrochloride 145307-34-2 GPCR/G Protein Neuroscience Dopamine Receptor A77636 Hydrochloride A-77636 Hydrochloride A77636 hydrochloride A 77636 Hydrochloride inhibitor inhibit

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