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Tandospirone

Name: Tandospirone
Brand: TargetMol
SKU: TQ0315
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TQ0315Cas No. 87760-53-0

Alias SM-3997, SM3997

Tandospirone (SM-3997) is a selective and potent 5-HT1A receptor partial agonist with anxiolytic and antidepressant activity that potentiates the anticardiac fibrotic effect of valsartan in spontaneously hypertensive rats, and can be used in the study of central nervous system disorders.

Tandospirone

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Purity: 99.94%

Catalog No. TQ0315Alias SM-3997, SM3997Cas No. 87760-53-0

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$30	In Stock	In Stock
5 mg	$48	In Stock	In Stock
10 mg	$77	In Stock	In Stock
25 mg	$139	In Stock	In Stock
50 mg	$198	In Stock	In Stock
100 mg	$316	In Stock	In Stock
200 mg	$453	-	In Stock
1 mL x 10 mM (in DMSO)	$53	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.94%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Tandospirone (SM-3997) is a selective and potent 5-HT1A receptor partial agonist with anxiolytic and antidepressant activity that potentiates the anticardiac fibrotic effect of valsartan in spontaneously hypertensive rats, and can be used in the study of central nervous system disorders.
Targets&IC50	brain hippocampal membranes (rat):9.4 nM (Kd), brain hippocampal membranes (rat):213 fmol/mg (Bmax), 5-HT1A receptor:27 nM (Ki)
In vitro	Tandospirone has negligible effects at 5-HT1B receptors, 5-HT uptake sites, β-adrenergic receptors, muscarinic cholinergic receptors, and benzodiazepine receptors. [1]3H-Tandospirone rapidly binds to rat brain hippocampal membranes and achieves binding in a high-affinity, reversible, and saturating fashion (Kd: 9.4 nM, Bmax: 213 fmol/mg protein). [2]
In vivo	Chronic administration of Tandospirone (0.2 and 1.0 mg/kg/day, but not 2.0 mg/kg/day) was effective in alleviating elevated levels of eLAC in the anterior cingulate cortex (mPFC) due to foot shock stress. [3] After acute administration of Tandospirone (0, 0.1 and 1 mg/kg, intraperitoneally) to rats, a significant reduction in the number of premature responses in a dose-dependent manner was observed, an index used to assess impulsive behavior. [4]
Synonyms	SM-3997, SM3997

Chemical Properties

Molecular Weight	383.49
Formula	C₂₁H₂₉N₅O₂
Cas No.	87760-53-0
Smiles	O=C1[C@]2([C@]([C@]3(C[C@@]2(CC3)[H])[H])(C(=O)N1CCCCN4CCN(CC4)C=5N=CC=CN5)[H])[H]
Relative Density.	1.239g/cm3

Storage & Solubility Information

Storage

keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble)

DMSO: 15 mg/mL (39.11 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.22 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6076 mL	13.0381 mL	26.0763 mL	130.3815 mL
5 mM	0.5215 mL	2.6076 mL	5.2153 mL	26.0763 mL
10 mM	0.2608 mL	1.3038 mL	2.6076 mL	13.0381 mL
20 mM	0.1304 mL	0.6519 mL	1.3038 mL	6.5191 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc