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Rifabutin

Name: Rifabutin
Brand: TargetMol
SKU: T1501
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1501Cas No. 72559-06-9

Alias LM-427, Ansamycin

Rifabutin (LM-427) inhibits bacterial DNA-dependent RNA polymerase, thereby suppressing the initiation of RNA formation and leading to inhibition of RNA synthesis and transcription. Rifabutin is a semisynthetic ansamycin antibiotic with potent antimycobacterial properties.

Rifabutin

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Purity: 99.7%

Catalog No. T1501Alias LM-427, AnsamycinCas No. 72559-06-9

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$30	In Stock	In Stock
25 mg	$42	In Stock	In Stock
50 mg	$55	In Stock	In Stock
100 mg	$79	In Stock	In Stock
500 mg	$238	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$32	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.7%

Color:Red to Purple

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Product Introduction

Bioactivity

Description	Rifabutin (LM-427) inhibits bacterial DNA-dependent RNA polymerase, thereby suppressing the initiation of RNA formation and leading to inhibition of RNA synthesis and transcription. Rifabutin is a semisynthetic ansamycin antibiotic with potent antimycobacterial properties.
In vitro	In chimeric mice, the combined use of Rifabutin (100 mg/kg) and emtricitabine (10 mg/kg) resulted in a 75% survival rate among mice infected with either Toxoplasma or Plasmodium. Additionally, in these mice, Rifabutin significantly increased human CYP3A4 mRNA expression (by 7.4-fold), CYP3A4 protein levels (by 3.0-fold), testosterone 6β-hydroxylase activity (by 2.4-fold), and dexamethasone 6-hydroxylase activity (by 1.9-fold).
In vivo	Rifabutin exhibits broad-spectrum antimicrobial activity and, compared to rifampicin, demonstrates higher potency in vitro against the Mycobacterium avium complex (MAC), Mycobacterium tuberculosis, and Mycobacterium leprae. It is also effective against Group A Streptococcus, Campylobacter jejuni, Neisseria gonorrhoeae, Haemophilus influenzae, Staphylococcus species, Haemophilus ducreyi, Helicobacter pylori, Neisseria meningitidis, Chlamydia trachomatis, and Toxoplasma gondii. While rifabutin is active against most atypical mycobacteria, including Mycobacterium kansasii, it is less effective against Mycobacterium chelonae. Its isoenzyme selectivity closely resembles that of rifampicin, although rifampin induces to a greater extent, by 2-4 times. Furthermore, rifabutin enhances the glucuronidation of β-estradiol, 4-hydroxytamoxifen, and 1-naphthol by 2-3 times.
Synonyms	LM-427, Ansamycin

Chemical Properties

Molecular Weight	847.00
Formula	C₄₆H₆₂N₄O₁₁
Cas No.	72559-06-9
Smiles	CO[C@H]1\C=C/O[C@@]2(C)Oc3c(C2=O)c2C4=NC5(CCN(CC(C)C)CC5)NC4=C(NC(=O)\C(C)=C/C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)C(=O)c2c(O)c3C
Relative Density.	1.339g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 38.00 mg/mL (44.86 mM), Sonication is recommended.

DMSO: 50.00 mg/mL (59.03 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.00 mg/mL (2.36 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1806 mL	5.9032 mL	11.8064 mL	59.0319 mL
5 mM	0.2361 mL	1.1806 mL	2.3613 mL	11.8064 mL
10 mM	0.1181 mL	0.5903 mL	1.1806 mL	5.9032 mL
20 mM	0.0590 mL	0.2952 mL	0.5903 mL	2.9516 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0236 mL	0.1181 mL	0.2361 mL	1.1806 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc