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D-Kynurenine

Name: D-Kynurenine
Brand: TargetMol
SKU: T10938
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10938Cas No. 13441-51-5

Alias ZINC901103, (R)-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid

D-Kynurenine (ZINC901103) is a metabolite of D-tryptophan and an agonist of GPR109B. D-Kynurenine activates AhR and promotes the conversion of the epithelium to mesenchyme. D-Kynurenine serves as a substrate in the fluorescence analysis of D-amino acid oxidase.

D-Kynurenine

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Purity: 99.68%

Catalog No. T10938Alias ZINC901103, (R)-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acidCas No. 13441-51-5

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$48	In Stock	In Stock
50 mg	$82	In Stock	In Stock
100 mg	$132	In Stock	In Stock
200 mg	$195	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.68%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	D-Kynurenine (ZINC901103) is a metabolite of D-tryptophan and an agonist of GPR109B. D-Kynurenine activates AhR and promotes the conversion of the epithelium to mesenchyme. D-Kynurenine serves as a substrate in the fluorescence analysis of D-amino acid oxidase.
In vitro	D-Kynurenine (10-100 µM) induces DER-enhancement and positively regulates the transfer of 95D cells, which is attenuated after siRNAAhr treatment in VIM and E-cadherin. D-Kynurenine (10 and 40 µM) significantly increases VIM expression and induces CYP1A1 upregulation. D-Kynurenine (10 µM) significantly attenuates the level of E-cadherin[4].
Synonyms	ZINC901103, (R)-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid

Chemical Properties

Molecular Weight	208.21
Formula	C₁₀H₁₂N₂O₃
Cas No.	13441-51-5
Smiles	N[C@H](CC(=O)c1ccccc1N)C(O)=O
Relative Density.	1.343 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 5 mg/mL (24.01 mM), Sonication and heating to 60℃ are recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	4.8028 mL	24.0142 mL	48.0284 mL	240.1422 mL
5 mM	0.9606 mL	4.8028 mL	9.6057 mL	48.0284 mL
10 mM	0.4803 mL	2.4014 mL	4.8028 mL	24.0142 mL
20 mM	0.2401 mL	1.2007 mL	2.4014 mL	12.0071 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc