Shopping Cart

Remove All
Your shopping cart is currently empty

Meclinertant

Name: Meclinertant
Brand: TargetMol
SKU: T16034
Price: 113 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T16034Cas No. 146362-70-1

Alias SR 48692

Meclinertant (SR 48692) is a neurotensin receptor-1 (NT1) antagonist that blocks neurotensin-induced excitation and can be used to study neurological disorders.

Meclinertant

🥰Excellent

Purity: 99.44%

Catalog No. T16034Alias SR 48692Cas No. 146362-70-1

Meclinertant (SR 48692) is a neurotensin receptor-1 (NT1) antagonist that blocks neurotensin-induced excitation and can be used to study neurological disorders.

Pack Size	Price	Availability
1 mg	$113	In Stock
2 mg	$198	In Stock
5 mg	$430	In Stock
10 mg	$833	In Stock
25 mg	$923	In Stock

Add to Cart

Add to Quotation

Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

Questions

Batch Information

Select Batch

Purity:99.44%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Meclinertant (SR 48692) is a neurotensin receptor-1 (NT1) antagonist that blocks neurotensin-induced excitation and can be used to study neurological disorders.
Targets&IC50	NTS1:5.6 nM, NTS2:20.4 nM
In vitro	The neurotensin-induced excitation was selectively blocked by the non-peptide neurotensin receptor antagonist SR 48692, primarily observed in the ventral part of the nucleus[1].
In vivo	SR 48692 can antagonize the induced turning behavior in mice and rats, and reverse the inhibition of amphetamine-induced hyperactivity in rats by neurotensin[2].
Synonyms	SR 48692

Chemical Properties

Molecular Weight	587.07
Formula	C₃₂H₃₁ClN₄O₅
Cas No.	146362-70-1
Smiles	O=C(O)C1(NC(=O)C2=NN(C=3C=CN=C4C=C(Cl)C=CC43)C(=C2)C=5C(OC)=CC=CC5OC)C6CC7CC(C6)CC1C7
Relative Density.	1.50 g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (34.07 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7034 mL	8.5169 mL	17.0337 mL	85.1687 mL
5 mM	0.3407 mL	1.7034 mL	3.4067 mL	17.0337 mL
10 mM	0.1703 mL	0.8517 mL	1.7034 mL	8.5169 mL
20 mM	0.0852 mL	0.4258 mL	0.8517 mL	4.2584 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc