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Meclinertant

Name: Meclinertant
Brand: TargetMol
SKU: T16034
Price: 113 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: SR 48692) Copy Product Info

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Synonyms: SR 48692

Catalog No. T16034 Copy Product Info

Purity: 99.44%

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Meclinertant (SR 48692) is a small-molecule compound and a neurotensin receptor-1 (NTSR1) antagonist with good selectivity and cell permeability. This compound can be used to study neurotensin signaling pathways and related neurological diseases, and serves as a potential diagnostic and therapeutic probe targeting NTSR1-positive tumors.

Cas No. 146362-70-1

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Pack Size	Price	USA Stock	Global Stock
1 mg	$113	In Stock	In Stock
2 mg	$198	In Stock	In Stock
5 mg	$430	In Stock	In Stock
10 mg	$833	In Stock	In Stock
25 mg	$923	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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Custom-made molecule. TargetMol’s expert synthesis team delivers cost-effective solutions. Contact us for inquiries. Committed to serving you.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.44%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Meclinertant (SR 48692) is a small-molecule compound and a neurotensin receptor-1 (NTSR1) antagonist with good selectivity and cell permeability. This compound can be used to study neurotensin signaling pathways and related neurological diseases, and serves as a potential diagnostic and therapeutic probe targeting NTSR1-positive tumors.
Targets & IC50	NTS2:20.4 nM, NTS1:5.6 nM
In vitro	Methods: Using extracellular recording techniques on rat dorsal raphe nucleus brain slices, the samples were pretreated with Meclinertant (SR 48692) (100 nM–1 μM) for 20 minutes to 2 hours. Results: Meclinertant (SR 48692) caused a concentration-dependent rightward shift in the concentration-response curve for NT, selectively blocking the excitation of serotonergic neurons induced by NT (1 μM) without affecting the response to phenylephrine. [1]
In vivo	Methods: In a mouse turning model induced by unilateral striatal injection of neurotensin (10 pg), Meclinertant (SR 48692) (80 μg/kg, oral, Tween 80 solvent) was pretreated for 30 min; in a rat hyperlocomotion model induced by amphetamine with neurotensin injection into the nucleus accumbens, Meclinertant (SR 48692) (0.1–1 mg/kg, oral) was pretreated. Results: Meclinertant (SR 48692) significantly antagonized turning behavior in mice, and dose-dependently reversed the inhibitory effect of neurotensin on amphetamine-induced hyperlocomotion.[2]
Synonyms	SR 48692

Chemical Properties

Molecular Weight	587.07
Formula	C₃₂H₃₁ClN₄O₅
Cas No.	146362-70-1
Smiles	O=C(O)C1(NC(=O)C2=NN(C=3C=CN=C4C=C(Cl)C=CC43)C(=C2)C=5C(OC)=CC=CC5OC)C6CC7CC(C6)CC1C7
Relative Density.	1.50 g/cm3

Storage & Solubility Information

Storage

Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (34.07 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7034 mL	8.5169 mL	17.0337 mL	85.1687 mL
5 mM	0.3407 mL	1.7034 mL	3.4067 mL	17.0337 mL
10 mM	0.1703 mL	0.8517 mL	1.7034 mL	8.5169 mL
20 mM	0.0852 mL	0.4258 mL	0.8517 mL	4.2584 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc