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Methicillin sodium salt

Name: Methicillin sodium salt
Brand: TargetMol
SKU: T0234
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: Meticillin sodium, Methicillin sodium) Copy Product Info

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Synonyms: Meticillin sodium, Methicillin sodium

Catalog No. T0234 Copy Product Info

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Methicillin sodium salt (Meticillin sodium) is a β-lactam antibiotic (natural product), a penicillin-binding protein inhibitor (anti-Staphylococcus aureus MIC=2.1 μg/mL), used for research on Staphylococcus aureus infections and inflammation-related studies.

Cas No. 132-92-3

Pack Size	Price	USA Stock	Global Stock	Quantity
10 mg	$29	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:93.36%

Color:White

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COA LCMS

Product Introduction

Methicillin sodium salt AI Summary

Methicillin sodium salt is characterized by a lipophilicity value of Log k = 0.658. It exhibits inhibitory activity against Bacillus subtilis NAD synthetase with an IC50 value exceeding 1000.0 nM and displays antimicrobial activity against various strains of Staphylococcus aureus, with minimum inhibitory concentrations (MIC) ranging from 1000.0 nM to 32000.0 nM. Additionally, it shows anti-methicillin-resistant activity against methicillin-resistant Staphylococcus aureus and coagulase-negative Staphylococci, with MIC values between 64.0 and 512.0 ug/mL. Methicillin sodium salt demonstrates inhibitory bioactivity in several assays: it inhibits JMJD2A-Tudor Domain (25118.9 nM), ATXN expression (28183.8 nM), and AMA1-RON (14125.4 nM), indicating potential antimalarial properties. It has been evaluated using the Drug Induced Liver Injury Prediction System (DILIps), showing a DILI positive result with a value of 1.0. This compound also inhibits sodium fluorescein uptake in OATP1B3 and OATP1B1-transfected CHO cells by 108.82% and 68.38% respectively at an equimolar substrate-inhibitor concentration of 10 uM. Moreover, Methicillin sodium salt shows low efficacy in inhibiting cell viability in Vero E6 cells infected with SARS-CoV-2 (BavPat1 strain), with an inhibition index of 0.2792, suggesting relatively weak activity compared to the control arbidol..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Methicillin sodium salt (Meticillin sodium) is a β-lactam antibiotic (natural product), a penicillin-binding protein inhibitor (anti-Staphylococcus aureus MIC=2.1 μg/mL), used for research on Staphylococcus aureus infections and inflammation-related studies.
Targets & IC50	S. aureus:2.1 μg/mL (MIC)
In vitro	Methods: Intracellular Staphylococcus aureus was treated with Methicillin sodium salt (100 μg/mL) for 18 hours, and bacterial survival was detected. Results: Methicillin sodium salt killed intracellular Staphylococcus aureus after 18 hours of treatment. [1]
In vivo	Methods: To study the in vivo antibacterial activity of Methicillin sodium salt against Enterococcus, infected animal models were intramuscularly injected with Methicillin sodium salt (42.5 and 85 mg/kg) four times daily for 21 consecutive days or until animal death, and the clearance of Enterococcus in leukocytes was detected. Results: Methicillin sodium salt administration effectively combated Enterococcus in leukocytes. [1] Methods: To evaluate the protective effect of Methicillin sodium salt on infected mice, infected mice were given a single intraperitoneal or subcutaneous injection of Methicillin sodium salt (400 mg/kg), and mouse survival was observed. Results: Compared with the control group, a single dose of Methicillin sodium salt improved the survival rate of infected mice and prevented death in infected mice. [2]
Synonyms	Meticillin sodium, Methicillin sodium

Chemical Properties

Molecular Weight	402.40
Formula	C₁₇H₁₉N₂NaO₆S
Cas No.	132-92-3
Smiles	O=C(N[C@@H]1C(N2[C@]1([H])SC(C)(C)[C@@H]2C([O-])=O)=O)C3=C(OC)C=CC=C3OC.[Na+]
Relative Density.	no data available

Storage & Solubility Information

Storage

Keep away from direct sunlight,Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 85 mg/mL (211.23 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (8.2 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4851 mL	12.4254 mL	24.8509 mL	124.2545 mL
5 mM	0.4970 mL	2.4851 mL	4.9702 mL	24.8509 mL
10 mM	0.2485 mL	1.2425 mL	2.4851 mL	12.4254 mL
20 mM	0.1243 mL	0.6213 mL	1.2425 mL	6.2127 mL
50 mM	0.0497 mL	0.2485 mL	0.4970 mL	2.4851 mL
100 mM	0.0249 mL	0.1243 mL	0.2485 mL	1.2425 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Keywords

β-lactamsemi-synthetic antibioticpenicillinPBPsMeticillinMethicillin sodium saltMethicillinintracellular infectionInhibitorinhibitinflammationinfectionBacterialAntibiotic

Related Tags: Methicillin sodium salt chemical structure | Methicillin sodium salt in vivo | Methicillin sodium salt in vitro | Methicillin sodium salt formula | Methicillin sodium salt molecular weight