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Verdiperstat (Synonyms: AZD3241, AZD 3241)

Name: Verdiperstat
Brand: TargetMol
SKU: T5463
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T5463 Copy Product Info

Purity: 99.36%

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Verdiperstat (AZD 3241) is a selective, irreversible and orally active myeloperoxidase inhibitor, with an IC50 of 630 nM, and can be used in the research of neurodegenerative brain disorders.

Verdiperstat

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Catalog No. T5463

Synonyms AZD3241, AZD 3241

Verdiperstat (AZD 3241) is a selective, irreversible and orally active myeloperoxidase inhibitor, with an IC50 of 630 nM, and can be used in the research of neurodegenerative brain disorders.

Cas No. 890655-80-8

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Pack Size	Price	USA Stock	Global Stock
1 mg	$32	In Stock	In Stock
2 mg	$45	In Stock	In Stock
5 mg	$72	In Stock	In Stock
10 mg	$122	In Stock	In Stock
25 mg	$222	In Stock	In Stock
50 mg	$369	In Stock	In Stock
100 mg	$571	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.36%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Verdiperstat (AZD 3241) is a selective, irreversible and orally active myeloperoxidase inhibitor, with an IC50 of 630 nM, and can be used in the research of neurodegenerative brain disorders.
Targets&IC50	Myeloperoxidase:630 nM
In vitro	Verdiperstat (AZD3241) functions as a myeloperoxidase (MPO) inhibitor, demonstrating potency with an IC50 value of 630 nM. It is primarily utilized in the study of neurodegenerative brain disorders[1]. By selectively and irreversibly targeting MPO, Verdiperstat (AZD3241) potentially reduces oxidative stress, consequently diminishing prolonged neuroinflammation.
Synonyms	AZD3241, AZD 3241

Chemical Properties

Molecular Weight	253.32
Formula	C₁₁H₁₅N₃O₂S
Cas No.	890655-80-8
Smiles	CC(C)OCCn1c2cc[nH]c2c(=O)[nH]c1=S
Relative Density.	1.34 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (592.14 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (15.79 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9476 mL	19.7379 mL	39.4758 mL	197.3788 mL
5 mM	0.7895 mL	3.9476 mL	7.8952 mL	39.4758 mL
10 mM	0.3948 mL	1.9738 mL	3.9476 mL	19.7379 mL
20 mM	0.1974 mL	0.9869 mL	1.9738 mL	9.8689 mL
50 mM	0.0790 mL	0.3948 mL	0.7895 mL	3.9476 mL
100 mM	0.0395 mL	0.1974 mL	0.3948 mL	1.9738 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc