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GSK2838232

Name: GSK2838232
Brand: TargetMol
SKU: T15436
Price: 54 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15436Cas No. 1443460-91-0

GSK2838232, a novel human immunodeficiency virus (HIV) maturation inhibitor, inhibits HIV reverse transcriptase activity across a broad panel of HIV-1 isolates.

GSK2838232

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Purity: 97.97%

Catalog No. T15436Cas No. 1443460-91-0

GSK2838232, a novel human immunodeficiency virus (HIV) maturation inhibitor, inhibits HIV reverse transcriptase activity across a broad panel of HIV-1 isolates.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$54	In Stock	In Stock
5 mg	$127	In Stock	In Stock
10 mg	$198	In Stock	In Stock
25 mg	$417	In Stock	In Stock
50 mg	$587	In Stock	In Stock
100 mg	$818	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$183	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:97.97%

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

GSK2838232 AI Summary

GSK2838232 exhibits broad-spectrum antiviral activity, demonstrating effectiveness against multiple viruses including SARS-CoV-2 and HIV-1. Against SARS-CoV-2, it inhibits cytotoxicity in both Caco-2 and VERO-6 cells, with inhibition rates of 3.87% and 0.01% at a concentration of 10 µM after 48 hours, respectively. Additionally, GSK2838232 inhibits the SARS-CoV-2 3CL-Pro protease, showing a 5.133% inhibition rate at 20 µM. For HIV-1, it shows potent antiviral activity with IC50 values of 0.81 nM and 0.71 nM against the NL4-3 strain and a V307A mutant strain, respectively. Furthermore, it exhibits inhibitory activity towards the human HDAC6 enzyme, with -8.21% inhibition using a commercial peptide substrate and -0.39% inhibition using a custom peptide substrate, highlighting its potential as an HDAC6 inhibitor..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

GSK2838232, a novel human immunodeficiency virus (HIV) maturation inhibitor, inhibits HIV reverse transcriptase activity across a broad panel of HIV-1 isolates.

Chemical Properties

Molecular Weight	809.56
Formula	C₄₈H₇₃ClN₂O₆
Cas No.	1443460-91-0
Smiles	[H][C@]12CC[C@]3([H])[C@@]4(C)CC[C@H](OC(=O)CC(C)(C)C(O)=O)C(C)(C)[C@]4([H])CC[C@@]3(C)[C@]1(C)CC[C@]1(CC(=O)C(C(C)C)=C21)[C@@H](O)CN(CCN(C)C)Cc1ccc(Cl)cc1
Relative Density.	1.17 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (61.76 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2352 mL	6.1762 mL	12.3524 mL	61.7619 mL
5 mM	0.2470 mL	1.2352 mL	2.4705 mL	12.3524 mL
10 mM	0.1235 mL	0.6176 mL	1.2352 mL	6.1762 mL
20 mM	0.0618 mL	0.3088 mL	0.6176 mL	3.0881 mL
50 mM	0.0247 mL	0.1235 mL	0.2470 mL	1.2352 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc