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JDTic Dihydrochloride

Name: JDTic Dihydrochloride
Brand: TargetMol
SKU: T11721L
Price: 99 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11721LCas No. 785835-79-2

JDTic Dihydrochloride is a high-affinity and selective κ-opioid receptor (KOR) antagonist that blocks dynorphin-KOR signalling, exhibiting antidepressant, anxiolytic, and anti-relapse effects against cocaine and nicotine.

JDTic Dihydrochloride

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Catalog No. T11721LCas No. 785835-79-2

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$99	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description

In vivo

Methods:
In a hangover-induced anxiety rat model, JDTic Dihydrochloride was administered via intraperitoneal injection at 3 mg/kg to assess anxiety-like behavior and at 10 mg/kg to evaluate alcohol-related behaviors, with a 2-hour pretreatment period.
Results:
JDTic Dihydrochloride (3 mg/kg, ip) significantly reversed anxiety-like behavior in hangover rats; the 10 mg/kg dose reduced alcohol self-administration, suppressed cue-induced reinstatement of alcohol seeking, and specifically blocked the effects of KOR agonists after 2 hours of pretreatment. [2]

Chemical Properties

Molecular Weight	538.55
Formula	C₂₈H₄₁Cl₂N₃O₃
Cas No.	785835-79-2
Smiles	C[C@]1(C2=CC(O)=CC=C2)[C@H](CN(CC1)C[C@H](C(C)C)NC([C@H]3CC4=CC=C(O)C=C4CN3)=O)C.Cl.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (148.55 mM), Sonication is recommended.

H2O: 40 mg/mL (74.27 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8568 mL	9.2842 mL	18.5684 mL	92.8419 mL
5 mM	0.3714 mL	1.8568 mL	3.7137 mL	18.5684 mL
10 mM	0.1857 mL	0.9284 mL	1.8568 mL	9.2842 mL
20 mM	0.0928 mL	0.4642 mL	0.9284 mL	4.6421 mL
50 mM	0.0371 mL	0.1857 mL	0.3714 mL	1.8568 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0186 mL	0.0928 mL	0.1857 mL	0.9284 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc