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JDTic Dihydrochloride

Name: JDTic Dihydrochloride
Brand: TargetMol
SKU: T11721L
Price: 106 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11721LCas No. 785835-79-2

JDTic Dihydrochloride is a high-affinity and selective κ-opioid receptor (KOR) antagonist that blocks dynorphin-KOR signalling, exhibiting antidepressant, anxiolytic, and anti-relapse effects against cocaine and nicotine.

JDTic Dihydrochloride

😃Good

Catalog No. T11721LCas No. 785835-79-2

Pack Size	Price	Availability
2 mg	$106	In Stock
25 mg	$668	10-14 weeks
50 mg	$868	10-14 weeks
100 mg	$1,290	10-14 weeks

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Product Introduction

Bioactivity

Description

In vivo

Methods:
In a hangover-induced anxiety rat model, JDTic Dihydrochloride was administered via intraperitoneal injection at 3 mg/kg to assess anxiety-like behavior and at 10 mg/kg to evaluate alcohol-related behaviors, with a 2-hour pretreatment period.
Results:
JDTic Dihydrochloride (3 mg/kg, ip) significantly reversed anxiety-like behavior in hangover rats; the 10 mg/kg dose reduced alcohol self-administration, suppressed cue-induced reinstatement of alcohol seeking, and specifically blocked the effects of KOR agonists after 2 hours of pretreatment. [2]

Chemical Properties

Molecular Weight	538.55
Formula	C₂₈H₄₁Cl₂N₃O₃
Cas No.	785835-79-2
Smiles	C[C@]1(C2=CC(O)=CC=C2)[C@H](CN(CC1)C[C@H](C(C)C)NC([C@H]3CC4=CC=C(O)C=C4CN3)=O)C.Cl.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (148.55 mM), Sonication is recommended.

H2O: 40 mg/mL (74.27 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8568 mL	9.2842 mL	18.5684 mL	92.8419 mL
5 mM	0.3714 mL	1.8568 mL	3.7137 mL	18.5684 mL
10 mM	0.1857 mL	0.9284 mL	1.8568 mL	9.2842 mL
20 mM	0.0928 mL	0.4642 mL	0.9284 mL	4.6421 mL
50 mM	0.0371 mL	0.1857 mL	0.3714 mL	1.8568 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0186 mL	0.0928 mL	0.1857 mL	0.9284 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc