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URAT1 inhibitor 3

Catalog No. T60724

URAT1 inhibitor 3 is a potent, orally active, selective inhibitor of URAT1(IC 50 = 0.8 nM). URAT1 inhibitor 3 shows urate-lowering efficacy that can be used in gout and hyperuricemi research [1].

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

URAT1 inhibitor 3, CAS N/A

Pack Size	Availability	Price/USD
25 mg	10-14 weeks	$ 1,520.00
50 mg	10-14 weeks	$ 1,980.00
100 mg	10-14 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description	URAT1 inhibitor 3 is a potent, orally active, selective inhibitor of URAT1(IC 50 = 0.8 nM). URAT1 inhibitor 3 shows urate-lowering efficacy that can be used in gout and hyperuricemi research [1].
In vitro	URAT1 inhibitor 3, at concentrations ranging from 0-400 μM, demonstrated low toxicity and inhibited the viability of HepG2 and HK2 cells only at higher concentrations, over periods of 24 and 72 hours, with minimal cytotoxic effects noted at the 24-hour mark and an inhibition rate of 34.75% for HepG2 cells and 35.9% for HK2 cells. Additionally, at doses between 0.01-100 μM, this inhibitor displayed reduced effectiveness against urate excretion transporters, possessing IC 50 values of 10.16 μM for OAT1 and 4.04 μM for ABCG2, indicating a lesser impact on these specific transporters compared to its overall cell viability effects.
In vivo	URAT1 inhibitor 3, administered via oral gavage to male Kunming mice in a hyperuricemia model, demonstrated urate-lowering efficacy at doses of 1-4 mg/kg in a single dose, significantly reducing serum urate levels in a dose-dependent manner without causing hepatic or renal toxicities when administered daily at 50 mg/kg over 14 days. Additionally, a single dose of 50 mg/kg resulted in a notable depletion of serum GSH levels from 42.23 μM to 20.39 μM, indicating its impact on oxidative stress markers in this model [1].

Molecular Weight	307.13
Formula	C14H8Cl2N2O2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
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The answer of 19.713 mg appears in the Mass box

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The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Molecule Formula

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Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

URAT1 inhibitor 3 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.