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MC180295

Name: MC180295
Brand: TargetMol
SKU: T5533
Price: 51 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: (rel)-MC180295) Copy Product Info

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Synonyms: (rel)-MC180295

Catalog No. T5533 Copy Product Info

Purity: 99.84%

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MC180295 ((rel)-MC180295) is a novel, potent, and highly selective CDK9 inhibitor with an IC50 of 5 nM, demonstrating over 22-fold selectivity compared to other CDKs.

Cas No. 2237942-08-2

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Pack Size	Price	USA Stock	Global Stock
1 mg	$51	In Stock	In Stock
5 mg	$133	In Stock	In Stock
10 mg	$197	In Stock	In Stock
25 mg	$335	In Stock	In Stock
50 mg	$472	In Stock	In Stock
100 mg	$672	In Stock	In Stock
200 mg	$886	-	In Stock
1 mL x 10 mM (in DMSO)	$146	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.84%

Appearance:Solid

Color:orange

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	MC180295 ((rel)-MC180295) is a novel, potent, and highly selective CDK9 inhibitor with an IC50 of 5 nM, demonstrating over 22-fold selectivity compared to other CDKs.
Targets & IC50	CDK2-CyclinE:367 nM, CDK6-CyclinD1:712 nM, CDK1-CyclinB:138 nM (cell free), CDK2-CyclinA:233 nM, CDK5-p25:186 nM (cell free), CDK4-CyclinD:112 nM (cell free), CDK9-CyclinT1:5 nM (cell free), CDK7-CyclinH-MAT1:555 nM, CDK3-CyclinE:399 nM, CDK5-p35:159 nM (cell free)
In vitro	MC180295 is a potent, selective CDK9-Cyclin T1 inhibitor with an IC50 of 5 nM, displaying at least 22-fold selectivity over other CDKs, including CDK1-Cyclin B (IC50, 138 nM), CDK2-Cyclin A (IC50, 233 nM), CDK2-Cyclin E (IC50, 367 nM), CDK3-Cyclin E (IC50, 399 nM), CDK4-Cyclin D (IC50, 112 nM), CDK5-P35 (IC50, 159 nM), and CDK5-P25 (IC50, 186 nM). MC180295 (0.1 μM) demonstrates broad anti-cancer activity in vitro.
In vivo	MC180295 (20 mg/kg, i.p., qod) demonstrates significant anti-tumor activity in mice with SW48 cells without inhibiting human T cell growth in vivo.
Synonyms	(rel)-MC180295

Chemical Properties

Molecular Weight	358.41
Formula	C₁₇H₁₈N₄O₃S
Cas No.	2237942-08-2
Smiles	Nc1nc(N[C@H]2C[C@@H]3CC[C@H]2C3)sc1C(=O)c1ccccc1[N+]([O-])=O
Relative Density.	1.462 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (418.52 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: < 10 mg/mL (27.9 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 10 mg/mL (27.9 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7901 mL	13.9505 mL	27.9010 mL	139.5050 mL
5 mM	0.5580 mL	2.7901 mL	5.5802 mL	27.9010 mL
10 mM	0.2790 mL	1.3951 mL	2.7901 mL	13.9505 mL
20 mM	0.1395 mL	0.6975 mL	1.3951 mL	6.9753 mL
50 mM	0.0558 mL	0.2790 mL	0.5580 mL	2.7901 mL
100 mM	0.0279 mL	0.1395 mL	0.2790 mL	1.3951 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc