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MC180295

Name: MC180295
Brand: TargetMol
SKU: T5533
Price: 51 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5533Cas No. 2237942-08-2

Alias (rel)-MC180295

MC180295 ((rel)-MC180295) is a novel, potent, and highly selective CDK9 inhibitor with an IC50 of 5 nM, demonstrating over 22-fold selectivity compared to other CDKs.

MC180295

🥰Excellent

Purity: 99.84%

Catalog No. T5533Alias (rel)-MC180295Cas No. 2237942-08-2

MC180295 ((rel)-MC180295) is a novel, potent, and highly selective CDK9 inhibitor with an IC50 of 5 nM, demonstrating over 22-fold selectivity compared to other CDKs.

Pack Size	Price	Availability
1 mg	$51	In Stock
5 mg	$133	In Stock
10 mg	$197	In Stock
25 mg	$335	In Stock
50 mg	$472	In Stock
100 mg	$672	In Stock
200 mg	$886	In Stock
1 mL x 10 mM (in DMSO)	$146	In Stock

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Purity:99.84%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	MC180295 ((rel)-MC180295) is a novel, potent, and highly selective CDK9 inhibitor with an IC50 of 5 nM, demonstrating over 22-fold selectivity compared to other CDKs.
Targets&IC50	CDK1-CyclinB:138 nM (cell free), CDK2-CyclinA:233 nM, CDK5-p35:159 nM (cell free), CDK7-CyclinH-MAT1:555 nM, CDK4-CyclinD:112 nM (cell free), CDK5-p25:186 nM (cell free), CDK3-CyclinE:399 nM, CDK2-CyclinE:367 nM, CDK6-CyclinD1:712 nM, CDK9-CyclinT1:5 nM (cell free)
In vitro	MC180295 is a potent, selective CDK9-Cyclin T1 inhibitor with an IC50 of 5 nM, displaying at least 22-fold selectivity over other CDKs, including CDK1-Cyclin B (IC50, 138 nM), CDK2-Cyclin A (IC50, 233 nM), CDK2-Cyclin E (IC50, 367 nM), CDK3-Cyclin E (IC50, 399 nM), CDK4-Cyclin D (IC50, 112 nM), CDK5-P35 (IC50, 159 nM), and CDK5-P25 (IC50, 186 nM). MC180295 (0.1 μM) demonstrates broad anti-cancer activity in vitro.
In vivo	MC180295 (20 mg/kg, i.p., qod) demonstrates significant anti-tumor activity in mice with SW48 cells without inhibiting human T cell growth in vivo.
Synonyms	(rel)-MC180295

Chemical Properties

Molecular Weight	358.41
Formula	C₁₇H₁₈N₄O₃S
Cas No.	2237942-08-2
Smiles	Nc1nc(N[C@H]2C[C@@H]3CC[C@H]2C3)sc1C(=O)c1ccccc1[N+]([O-])=O
Relative Density.	1.462 g/cm3 (Predicted)
Color	orange
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 70 mg/mL (195.31 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7901 mL	13.9505 mL	27.9010 mL	139.5050 mL
5 mM	0.5580 mL	2.7901 mL	5.5802 mL	27.9010 mL
10 mM	0.2790 mL	1.3951 mL	2.7901 mL	13.9505 mL
20 mM	0.1395 mL	0.6975 mL	1.3951 mL	6.9753 mL
50 mM	0.0558 mL	0.2790 mL	0.5580 mL	2.7901 mL
100 mM	0.0279 mL	0.1395 mL	0.2790 mL	1.3951 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc