Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

Nitro-PDS-Tubulysin M

Nitro-PDS-Tubulysin M
Nitro-PDS-Tubulysin M, an ADC (Antibody-Drug Conjugate) drug-linker conjugate, exhibits potent antitumor activity. It employs Tubulysin M, a tubulin polymerization inhibitor, connected through the Nitro-PDS ADC linker.
Catalog No. T18504Cas No. 1941168-69-9

Resource Download

Nitro-PDS-Tubulysin M

Catalog No. T18504Cas No. 1941168-69-9

Nitro-PDS-Tubulysin M, an ADC (Antibody-Drug Conjugate) drug-linker conjugate, exhibits potent antitumor activity. It employs Tubulysin M, a tubulin polymerization inhibitor, connected through the Nitro-PDS ADC linker.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
100 mgInquiryBackorder
500 mgInquiryBackorder
Bulk & Custom
Add to Cart
Questions
View More

Product Introduction

Bioactivity
Description
Nitro-PDS-Tubulysin M, an ADC (Antibody-Drug Conjugate) drug-linker conjugate, exhibits potent antitumor activity. It employs Tubulysin M, a tubulin polymerization inhibitor, connected through the Nitro-PDS ADC linker.
In vitro
The chemical compound ADC2-2 (anti-CD22 10F4v3 LC K149C Nitro-PDS-Tubulysin M) exhibits specific cytotoxicity against WSU-DLCL2 human diffuse large B-cell lymphoma tumors, achieving a half-maximal inhibitory concentration (IC50) of 0.147 nM. Similarly, ADC2-1 (anti-Napi2b 10H1.11.4B LC K149C Nitro-PDS-Tubulysin M) demonstrates targeted toxicity in human ovarian cancer cell lines IGROV-1 and OVCAR-3x2.1, with IC50 values of 2.07 nM and 1.004 nM, respectively[1].
Chemical Properties
Molecular Weight1106.4
FormulaC54H73N8O11S3
Cas No.1941168-69-9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
%Tween 80
%ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Related Tags: buy Nitro-PDS-Tubulysin M | purchase Nitro-PDS-Tubulysin M | Nitro-PDS-Tubulysin M cost | order Nitro-PDS-Tubulysin M | Nitro-PDS-Tubulysin M chemical structure | Nitro-PDS-Tubulysin M in vitro | Nitro-PDS-Tubulysin M formula | Nitro-PDS-Tubulysin M molecular weight