Nitro-PDS-Tubulysin M

Name: Nitro-PDS-Tubulysin M
Brand: TargetMol
SKU: T18504
Rating: 4.5 (1 reviews)

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Catalog No. T18504Cas No. 1941168-69-9

Nitro-PDS-Tubulysin M, an ADC (Antibody-Drug Conjugate) drug-linker conjugate, exhibits potent antitumor activity. It employs Tubulysin M, a tubulin polymerization inhibitor, connected through the Nitro-PDS ADC linker.

Nitro-PDS-Tubulysin M

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Catalog No. T18504Cas No. 1941168-69-9

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Product Introduction

Bioactivity

Description

In vitro

The chemical compound ADC2-2 (anti-CD22 10F4v3 LC K149C Nitro-PDS-Tubulysin M) exhibits specific cytotoxicity against WSU-DLCL2 human diffuse large B-cell lymphoma tumors, achieving a half-maximal inhibitory concentration (IC50) of 0.147 nM. Similarly, ADC2-1 (anti-Napi2b 10H1.11.4B LC K149C Nitro-PDS-Tubulysin M) demonstrates targeted toxicity in human ovarian cancer cell lines IGROV-1 and OVCAR-3x2.1, with IC50 values of 2.07 nM and 1.004 nM, respectively[1].

Chemical Properties

Molecular Weight	1106.4
Formula	C₅₄H₇₃N₈O₁₁S₃
Cas No.	1941168-69-9
Smiles	C([N+]1(C)[C@@H](C(N[C@H](C(N([C@H](C[C@@H](OC(C)=O)C2=NC(C(N[C@@H](CC3=CC=CC=C3)C[C@@H](C(O)=O)C)=O)=CS2)C(C)C)C)=O)[C@H](CC)C)=O)CCCC1)C4=CC=C(NC(OC[C@H](SSC=5C=CC(N(=O)=O)=NC5)C)=O)C=C4
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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