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Anti-Phospho-MAPT (Ser416) Polyclonal Antibody

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Catalog No. TMAC-03981

Anti-Phospho-MAPT (Ser416) Polyclonal Antibody is a Rabbit antibody targeting Phospho-MAPT (Ser416). Anti-Phospho-MAPT (Ser416) Polyclonal Antibody can be used in WB.

Anti-Phospho-MAPT (Ser416) Polyclonal Antibody

Anti-Phospho-MAPT (Ser416) Polyclonal Antibody

😃Good
Catalog No. TMAC-03981
Anti-Phospho-MAPT (Ser416) Polyclonal Antibody is a Rabbit antibody targeting Phospho-MAPT (Ser416). Anti-Phospho-MAPT (Ser416) Polyclonal Antibody can be used in WB.
Pack SizePriceAvailabilityQuantity
50 μL$2187-10 days
100 μL$3167-10 days
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Product Introduction

Bioactivity
Description
Anti-Phospho-MAPT (Ser416) Polyclonal Antibody is a Rabbit antibody targeting Phospho-MAPT (Ser416). Anti-Phospho-MAPT (Ser416) Polyclonal Antibody can be used in WB.
Ig Type
IgG
Reactivity
Human,Mouse,Rat
Application
Antibody Type
Polyclonal
Host SpeciesRabbit
ConstructionPolyclonal Antibody
PurificationAntibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
AppearanceLiquid
FormulationSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Research BackgroundTau is a heterogeneous microtubule-associated protein that promotes and stabilizes microtubule assembly, especially in axons. Six isoforms with different amino-terminal inserts and different numbers of tandem repeats near the carboxy-terminus have been identified, and tau is hyperphosphorylated at approximately 25 sites by ERK, GSK-3 and CDK5 (1-2). Phosphorylation decreases the ability of tau to bind to microtubules. Neurofibrillary tangles are a major hallmark of Alzheimer's disease and these tangles are bundles of paired helical filaments composed of hyperphosphorylated tau. In particular, phosphorylation of Ser396 by GSK-3 or CDK5 destabilizes microtubules in Alzheimer's disease. Furthermore, inclusions of tau are found in a number of other neurodegenerative diseases, collectively known as tauopathies (1,3).
Related Conjugates and Formulations
Conjucates
Unconjugated
Others Formats
Phospho
Antigen Details
Immunogen
Peptide sequence around phosphorylation site of serine 416 (T-G-S(p)-I-D) derived from Human Tau
Antigen Species
human
Uniprot ID
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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