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N-Boc-4-hydroxy-L-proline methyl ester

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Catalog No. FL0195Cas No. 102195-79-9

N-Boc-cis-4-hydroxy-L-proline methyl ester serves as a non-cleavable linker in antibody-drug conjugate (ADC) synthesis and functions as an alkyl chain-based PROTAC linker for PROTAC construction [2].

N-Boc-4-hydroxy-L-proline methyl ester

N-Boc-4-hydroxy-L-proline methyl ester

🥰Excellent
Catalog No. FL0195Cas No. 102195-79-9
N-Boc-cis-4-hydroxy-L-proline methyl ester serves as a non-cleavable linker in antibody-drug conjugate (ADC) synthesis and functions as an alkyl chain-based PROTAC linker for PROTAC construction [2].
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200 mg$29-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:≥98%
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Product Introduction

Bioactivity
Description
N-Boc-cis-4-hydroxy-L-proline methyl ester serves as a non-cleavable linker in antibody-drug conjugate (ADC) synthesis and functions as an alkyl chain-based PROTAC linker for PROTAC construction [2].
In vitro
ADCs consist of an antibody linked to a cytotoxin via an ADC linker, enabling them to deliver cytotoxic agents to specific cells [1]. PROTACs are bifunctional molecules with two ligands connected by a linker: one binds to an E3 ubiquitin ligase and the other to the target protein, leveraging the cell's ubiquitin-proteasome system for the selective degradation of target proteins [2].
Chemical Properties
Molecular Weight245.27
FormulaC11H19NO5
Cas No.102195-79-9
SmilesCOC(=O)[C@@H]1C[C@H](O)CN1C(=O)OC(C)(C)C
Relative Density.1.216 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

N-Boc-4-hydroxy-L-proline methyl esterCompound FL0195ADCLinkerADC Linker
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