Powder: -20°C for 3 years | In solvent: -80°C for 1 year
N-Boc-cis-4-hydroxy-L-proline methyl ester serves as a non-cleavable linker in antibody-drug conjugate (ADC) synthesis and functions as an alkyl chain-based PROTAC linker for PROTAC construction[2].
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Description | N-Boc-cis-4-hydroxy-L-proline methyl ester serves as a non-cleavable linker in antibody-drug conjugate (ADC) synthesis and functions as an alkyl chain-based PROTAC linker for PROTAC construction[2]. |
In vitro | ADCs consist of an antibody linked to a cytotoxin via an ADC linker, enabling them to deliver cytotoxic agents to specific cells [1]. PROTACs are bifunctional molecules with two ligands connected by a linker: one binds to an E3 ubiquitin ligase and the other to the target protein, leveraging the cell's ubiquitin-proteasome system for the selective degradation of target proteins [2]. |
Molecular Weight | 245.27 |
Formula | C11H19NO5 |
CAS No. | 102195-79-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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N-Boc-4-hydroxy-L-proline methyl ester 102195-79-9 Compound FL0195 inhibitor inhibit