Shopping Cart

Your shopping cart is currently empty

Fondaparinux sodium

Name: Fondaparinux sodium
Brand: TargetMol
SKU: T4076
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: SR-90107A, Natural heparin pentasaccharide Sodium, Fondaparin sodium, Arixtra) Copy Product Info

😃Good

Synonyms: SR-90107A, Natural heparin pentasaccharide Sodium, Fondaparin sodium, Arixtra

Catalog No. T4076 Copy Product Info

Purity: 99.88%

😃Good

Fondaparinux sodium (Arixtra, SR-90107A) is a synthetic heparin anticoagulant and an antithrombin-dependent factor Xa inhibitor (IC50=1909 nM), with high selectivity, low immunogenicity, and favorable pharmacokinetic properties, used for the prevention and treatment of thrombotic diseases.

Cas No. 114870-03-0

Pack Size	Price	USA Stock	Global Stock
1 mg	$33	In Stock	In Stock
2 mg	$46	In Stock	In Stock
5 mg	$71	In Stock	In Stock
10 mg	$129	In Stock	In Stock
25 mg	$283	In Stock	In Stock
50 mg	$492	In Stock	In Stock
100 mg	$702	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

Add to Cart

Add to Quotation

For research use only—not for human use. No sales to individuals. Use as intended only.

Questions

Batch Information

Select Batch

Purity:99.88%

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Fondaparinux sodium (Arixtra, SR-90107A) is a synthetic heparin anticoagulant and an antithrombin-dependent factor Xa inhibitor (IC50=1909 nM), with high selectivity, low immunogenicity, and favorable pharmacokinetic properties, used for the prevention and treatment of thrombotic diseases.
In vitro	Methods: Purified human antithrombin III and factor Xa were used, and the inhibitory activity of Fondaparinux sodium against factor Xa was determined by chromogenic substrate assay. Results: The Kd value of Fondaparinux sodium for antithrombin III was 48±11 nM, which increased the inhibition rate of antithrombin III against factor Xa by 340-fold, confirming its indirect inhibition of factor Xa through selective binding to antithrombin III. [1] Methods: Ovarian cancer OVCAR-3 and gastric signet ring cell carcinoma KATO-III cell lines were used. Cell supernatants were collected and co-incubated with Fondaparinux sodium (10^6 cells, 37℃, 2 hours, pH 5.0), and residual anti-Xa activity was detected to evaluate its degradation. Results: After incubation with OVCAR-3 and KATO-III cell supernatants, the residual activity of Fondaparinux sodium was 70% and 80% of control, respectively, indicating that cancer cell-derived heparanase can degrade Fondaparinux sodium under acidic conditions. [2]
In vivo	Methods: A Wistar rat venous thrombosis model was used. Fondaparinux sodium was administered by single subcutaneous injection at 300 IU/kg, thrombosis was induced 1 hour after dosing, and thrombi were harvested and weighed 30 minutes later; the control group received saline. Results: Compared with the saline group, Fondaparinux sodium significantly reduced venous thrombus weight (P<0.05), confirming its in vivo antithrombotic effect.[3]
Synonyms	SR-90107A, Natural heparin pentasaccharide Sodium, Fondaparin sodium, Arixtra

Chemical Properties

Molecular Weight	1728.08
Formula	C₃₁H₄₃N₃Na₁₀O₄₉S₈
Cas No.	114870-03-0
Smiles	[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].CO[C@H]1O[C@H](COS([O-])(=O)=O)[C@@H](O[C@@H]2O[C@H]([C@@H](O[C@H]3O[C@H](COS([O-])(=O)=O)[C@@H](O[C@@H]4O[C@@H]([C@@H](O[C@H]5O[C@H](COS([O-])(=O)=O)[C@@H](O)[C@H](O)[C@H]5NS([O-])(=O)=O)[C@H](O)[C@H]4O)C([O-])=O)[C@H](OS([O-])(=O)=O)[C@H]3NS([O-])(=O)=O)[C@H](O)[C@H]2OS([O-])(=O)=O)C([O-])=O)[C@H](O)[C@H]1NS([O-])(=O)=O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 17.36 mM, Sonication is recommended.

DMSO: 60 mg/mL (34.72 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	0.5787 mL	2.8934 mL	5.7868 mL	28.9338 mL
5 mM	0.1157 mL	0.5787 mL	1.1574 mL	5.7868 mL
10 mM	0.0579 mL	0.2893 mL	0.5787 mL	2.8934 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.0289 mL	0.1447 mL	0.2893 mL	1.4467 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

InhibitorinhibitFxaFondaparinux sodiumFondaparinuxFondaparinFactorXaFactor Xa

Related Tags: Fondaparinux sodium chemical structure | Fondaparinux sodium in vivo | Fondaparinux sodium in vitro | Fondaparinux sodium formula | Fondaparinux sodium molecular weight