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Fondaparinux sodium

Name: Fondaparinux sodium
Brand: TargetMol
SKU: T4076
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4076Cas No. 114870-03-0

Alias SR-90107A, Natural heparin pentasaccharide Sodium, Fondaparin sodium, Arixtra

Fondaparinux sodium (SR-90107A) is an antithrombin-dependent factor Xa inhibitor with antithrombotic activity.

Fondaparinux sodium

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Purity: 99.88%

Catalog No. T4076Alias SR-90107A, Natural heparin pentasaccharide Sodium, Fondaparin sodium, ArixtraCas No. 114870-03-0

Fondaparinux sodium (SR-90107A) is an antithrombin-dependent factor Xa inhibitor with antithrombotic activity.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$33	In Stock	In Stock
2 mg	$46	In Stock	In Stock
5 mg	$71	In Stock	In Stock
10 mg	$129	In Stock	In Stock
25 mg	$283	In Stock	In Stock
50 mg	$492	In Stock	In Stock
100 mg	$702	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.88%

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Fondaparinux sodium (SR-90107A) is an antithrombin-dependent factor Xa inhibitor with antithrombotic activity.
In vitro	Fondaparinux sodium, the pioneering agent in a novel class of anticoagulants, selectively targets factor Xa with IC50 values (anti-Xa IU/ml) of 0.59±0.05 for activated monocytes (ac-M) and 0.17±0.03 for monocyte-derived microparticles (MMPs)[2].
In vivo	Fondaparinux sodium exhibits a linear, dose-dependent pharmacokinetic profile ensuring a highly predictable response. It is fully bioavailable (100%), with a quick onset and a half-life of 14 to 16 hours, providing prolonged antithrombotic effects throughout a 24-hour period. Notably, the drug does not impact prothrombin time, activated partial thromboplastin time, or platelet function and aggregation[1].
Synonyms	SR-90107A, Natural heparin pentasaccharide Sodium, Fondaparin sodium, Arixtra

Chemical Properties

Molecular Weight	1728.08
Formula	C₃₁H₄₃N₃Na₁₀O₄₉S₈
Cas No.	114870-03-0
Smiles	[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].CO[C@H]1O[C@H](COS([O-])(=O)=O)[C@@H](O[C@@H]2O[C@H]([C@@H](O[C@H]3O[C@H](COS([O-])(=O)=O)[C@@H](O[C@@H]4O[C@@H]([C@@H](O[C@H]5O[C@H](COS([O-])(=O)=O)[C@@H](O)[C@H](O)[C@H]5NS([O-])(=O)=O)[C@H](O)[C@H]4O)C([O-])=O)[C@H](OS([O-])(=O)=O)[C@H]3NS([O-])(=O)=O)[C@H](O)[C@H]2OS([O-])(=O)=O)C([O-])=O)[C@H](O)[C@H]1NS([O-])(=O)=O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 17.36 mM, Sonication is recommended.

DMSO: 60 mg/mL (34.72 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	0.5787 mL	2.8934 mL	5.7868 mL	28.9338 mL
5 mM	0.1157 mL	0.5787 mL	1.1574 mL	5.7868 mL
10 mM	0.0579 mL	0.2893 mL	0.5787 mL	2.8934 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.0289 mL	0.1447 mL	0.2893 mL	1.4467 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc