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TR antagonist 1

Name: TR antagonist 1
Brand: TargetMol
SKU: T13435
Price: 299 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13435Cas No. 500794-88-7

TR antagonist 1 is a highly potent thyroid hormone receptor (TR) antagonist (IC50 of 36 and 22 nM for TRα and TRβ, respectively) that can be used to study diseases caused by endocrine abnormalities.

TR antagonist 1

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Purity: 99.57%

Catalog No. T13435Cas No. 500794-88-7

Pack Size	Price	Availability	Quantity
1 mg	$299	In Stock

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Purity:99.57%

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COA HPLC

Product Introduction

Bioactivity

Description	TR antagonist 1 is a highly potent thyroid hormone receptor (TR) antagonist (IC50 of 36 and 22 nM for TRα and TRβ, respectively) that can be used to study diseases caused by endocrine abnormalities.
Targets&IC50	THRα:36 nM, Thyroid hormone β:22 nM
In vitro	TR antagonist 1 is a high-affinity thyroid hormone receptor (TR) antagonist with IC50 s of 36 and 22 nM for TRα and TRβ, respectively[1].
In vivo	In the cholesterol-fed rat model, treatment with TR antagonist 1 reduces heart rate and shows a tendency to increase the proportion of low-density lipoprotein cholesterol (LDL-C) to a certain extent [1].

Chemical Properties

Molecular Weight	561.26
Formula	C₂₅H₂₃Br₂NO₄
Cas No.	500794-88-7
Smiles	CC(C)c1cc(Oc2c(Br)cc(CCC(O)=O)cc2Br)cc(\C=C\c2ccncc2)c1O
Relative Density.	1.553 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (89.13 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7817 mL	8.9085 mL	17.8171 mL	89.0853 mL
5 mM	0.3563 mL	1.7817 mL	3.5634 mL	17.8171 mL
10 mM	0.1782 mL	0.8909 mL	1.7817 mL	8.9085 mL
20 mM	0.0891 mL	0.4454 mL	0.8909 mL	4.4543 mL
50 mM	0.0356 mL	0.1782 mL	0.3563 mL	1.7817 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc