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Crustecdysone

Name: Crustecdysone
Brand: TargetMol
SKU: T2881
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T2881Cas No. 5289-74-7

Alias Hydroxyecdysone, Ecdysterone, Commisterone, B-ecdysone, 20-Hydroxyecdysone

Crustecdysone (Hydroxyecdysone) is a steroid hormone that regulates the processes of molting or ecdysis in insects.

Crustecdysone

🥰Excellent

Purity: 99.67%

Catalog No. T2881Alias Hydroxyecdysone, Ecdysterone, Commisterone, B-ecdysone, 20-HydroxyecdysoneCas No. 5289-74-7

Crustecdysone (Hydroxyecdysone) is a steroid hormone that regulates the processes of molting or ecdysis in insects.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$32	In Stock	In Stock
10 mg	$43	In Stock	In Stock
25 mg	$67	In Stock	In Stock
50 mg	$95	In Stock	In Stock
100 mg	$138	In Stock	In Stock
500 mg	$339	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.67%

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Crustecdysone (Hydroxyecdysone) is a steroid hormone that regulates the processes of molting or ecdysis in insects.
In vitro	In C57BL/6J mice fed a high-fat diet, oral administration of 20-Hydroxyecdysone (10 mg/kg/day, for 13 weeks) was able to improve obesity and insulin levels, reducing body weight and body fat content.
In vivo	In cells induced by CoCl2, 20-Hydroxyecdysone reduces the production of reactive oxygen species (ROS), diminishes mitochondrial membrane depolarization, and suppresses the release of cytochrome c into the cytoplasm, thereby ameliorating cell damage. In H4IIE cells, 20-Hydroxyecdysone effectively lowers the expression of phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase), resulting in decreased glucose production.
Synonyms	Hydroxyecdysone, Ecdysterone, Commisterone, B-ecdysone, 20-Hydroxyecdysone

Chemical Properties

Molecular Weight	480.63
Formula	C₂₇H₄₄O₇
Cas No.	5289-74-7
Smiles	CC(C)(O)CCC(O)C(C)(O)C1CCC2(O)C3=CC(=O)C4CC(O)C(O)CC4(C)C3CCC12C
Relative Density.	1.0760 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (260.08 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 89 mg/mL (185.17 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.16 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0806 mL	10.4030 mL	20.8060 mL	104.0301 mL
5 mM	0.4161 mL	2.0806 mL	4.1612 mL	20.8060 mL
10 mM	0.2081 mL	1.0403 mL	2.0806 mL	10.4030 mL
20 mM	0.1040 mL	0.5202 mL	1.0403 mL	5.2015 mL
50 mM	0.0416 mL	0.2081 mL	0.4161 mL	2.0806 mL
100 mM	0.0208 mL	0.1040 mL	0.2081 mL	1.0403 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc