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Nortriptyline hydrochloride

Name: Nortriptyline hydrochloride
Brand: TargetMol
SKU: T1327
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1327Cas No. 894-71-3

Alias EN-7048 hydrochloride, ELF-101 hydrochloride, Desmethylamitriptyline hydrochloride, Desitriptyline HCl

Nortriptyline hydrochloride (ELF-101 hydrochloride) is a metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.

Nortriptyline hydrochloride

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Purity: 99.85%

Catalog No. T1327Alias EN-7048 hydrochloride, ELF-101 hydrochloride, Desmethylamitriptyline hydrochloride, Desitriptyline HClCas No. 894-71-3

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$33	In Stock	In Stock
50 mg	$46	In Stock	In Stock
100 mg	$64	In Stock	In Stock
500 mg	$143	In Stock	In Stock
1 g	$198	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.85%

Color:White

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Product Introduction

Nortriptyline hydrochloride AI Summary

Nortriptyline hydrochloride displays a broad spectrum of bioactivities across various cellular and molecular assays. It demonstrates antiplasmodial activity against different strains of Plasmodium falciparum with IC50 values ranging from 2238.7 nM to 12589.25 nM, suggesting potential in malaria treatment. Additionally, it acts as a modulator of Lamin A splicing, induces erasure of genomic imprints, and enhances SMN2 splice variant expression at varying potencies. The compound also exhibits antiviral properties, showing inhibitory effects against virus entry for Lassa and Marburg viruses and SARS-CoV-2. Specifically, it inhibits SARS-CoV-2-induced cytotoxicity in Vero E6 cells and Caco-2 cells, and inhibits the SARS-CoV-2 3CL-Pro protease by 31.79% at 20 µM. Furthermore, Nortriptyline hydrochloride shows antifungal activity against Candida albicans and Cryptococcus neoformans, albeit with low percentages of inhibition. Its antibacterial activity was noted against multiple strains including Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, and Staphylococcus aureus MRSA, demonstrating varying levels of efficacy. In the context of cancer, Nortriptyline hydrochloride inhibits the growth of various human tumor cell lines with GI50 values from 6137.62 nM to 36982.82 nM. It also disrupts the Norepinephrine transporter (NET) with a potent IC50 value of 40.0 nM. Overall, Nortriptyline hydrochloride is a multi-target compound with activities spanning antimalarial, antiviral, antifungal, antibacterial, anticancer, and transporter inhibition properties, indicating its significant potential for therapeutic development..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Nortriptyline hydrochloride (ELF-101 hydrochloride) is a metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.
Synonyms	EN-7048 hydrochloride, ELF-101 hydrochloride, Desmethylamitriptyline hydrochloride, Desitriptyline HCl

Chemical Properties

Molecular Weight	299.84
Formula	C₁₉H₂₂ClN
Cas No.	894-71-3
Smiles	Cl.CNCC\C=C1\c2ccccc2CCc2ccccc12
Relative Density.	no data available

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 54 mg/mL (180.1 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.67 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol

	1mg	5mg	10mg	50mg
1 mM	3.3351 mL	16.6756 mL	33.3511 mL	166.7556 mL
5 mM	0.6670 mL	3.3351 mL	6.6702 mL	33.3511 mL
10 mM	0.3335 mL	1.6676 mL	3.3351 mL	16.6756 mL
20 mM	0.1668 mL	0.8338 mL	1.6676 mL	8.3378 mL
50 mM	0.0667 mL	0.3335 mL	0.6670 mL	3.3351 mL
100 mM	0.0334 mL	0.1668 mL	0.3335 mL	1.6676 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc