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NRAS Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 22.29 kDa and the accession number is P01111.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
100 μg | $812 | 7-10 days | |
1 mg | $5,300 | 7-10 days |
Biological Activity | Activity testing is not tested. It is theoretically active, but we cannot guarantee it. |
Description | NRAS Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 22.29 kDa and the accession number is P01111. |
Species | Human |
Expression System | E. coli |
Tag | N-His |
Accession Number | P01111 |
Synonyms | NS6,NRAS1,N-ras,neuroblastoma RAS viral (v-ras) oncogene homolog,NCMS,CMNS,ALPS4 |
Construction | Met1-Cys186 |
Protein Purity | > 95% as determined by Tris-Bis PAGE; > 90% as determined by HPLC |
Molecular Weight | 22.29 kDa (Predicted and reducing conditions) |
Endotoxin | Less than 1EU per μg by the LAL method. |
Formulation | Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
Stability & Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping | In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice. |
Research Background | NRas is a key mediator of the mitogenic pathway in normal cells and in cancer cells. Its dynamics and nanoscale organization at the plasma membrane (PM) facilitate its signaling. NRas activity is mediated and regulated by its dynamic interactions with functional (Grb2, BRAF, NF1, and GPI-nucleated) clusters at the PM. |
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