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Anti-GABRA1 Polyclonal Antibody
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Catalog No. TMAB-00729
Alias Gamma-aminobutyric acid receptor subunit alpha-1, GABRA1, GABA(A) receptor subunit alpha-1 (GABAAR subunit alpha-1)
Anti-GABRA1 Polyclonal Antibody is a Rabbit antibody targeting GABRA1. Anti-GABRA1 Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P,WB.
Anti-GABRA1 Polyclonal Antibody
Anti-GABRA1 Polyclonal Antibody
😃Good
Catalog No. TMAB-00729Alias Gamma-aminobutyric acid receptor subunit alpha-1, GABRA1, GABA(A) receptor subunit alpha-1 (GABAAR subunit alpha-1)
Anti-GABRA1 Polyclonal Antibody is a Rabbit antibody targeting GABRA1. Anti-GABRA1 Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P,WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $220 | 7-10 days | |
| 100 μL | $373 | 7-10 days | |
| 200 μL | $529 | 7-10 days |
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-GABRA1 Polyclonal Antibody is a Rabbit antibody targeting GABRA1. Anti-GABRA1 Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P,WB. |
| Synonyms | Gamma-aminobutyric acid receptor subunit alpha-1, GABRA1, GABA(A) receptor subunit alpha-1 (GABAAR subunit alpha-1) |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat (predicted:Chicken,Dog,Cow,Horse) |
| Verified Activity | 1. Sample: Brain (Mouse) Lysate at 40 μg Primary: Anti-GABA A Receptor (TMAB-00729) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/10000 dilution Predicted band size: 52 kDa Observed band size: 52 kDa 2. Paraformaldehyde-fixed, paraffin embedded (rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 min; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (GABRA1 GABA A Receptor alpha 1) Polyclonal Antibody, Unconjugated (TMAB-00729) at 1:200 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructionsand DAB staining. 3. Sample: Cerebrum (Mouse) Lysate at 40 μg Cerebellum (Rat) Lysate at 40 μg Primary: Anti-GABRA1/GABA A Receptor alpha 1 (TMAB-00729) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 52 kDa Observed band size: 52 kDa 4. Paraformaldehyde-fixed, paraffin embedded (mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 min; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (GABRA1 GABA A Receptor alpha 1) Polyclonal Antibody, Unconjugated (TMAB-00729) at 1:200 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructionsand DAB staining. |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | Highly expressed in brain and weakly in heart, small intestine and uterus. Isoform 1A is mostly expressed in granular cell and molecular layer. Isoform 1B is mostly expressed in Purkinje cells. Isoform 1E is predominantly expressed in peripheral tissues a |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | GAD-65 and GAD-67, glutamate decarboxylases, function to catalyze the production of GABA (g-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl-conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct. Members of the GABAA receptor family include GABAA R alpha 1-6, GABAA R beta 1-3, GABAA R©1-3, GABAA R∂, GABAA R gamma, GABAA R delta 1 and GABAA R delta 2. The GABAB family is composed of GABAB R1 alpha and GABAB R1 beta. GABA transporters have also been identified and include GABA T-1, GABA T-2 and GABA T-3 (also designated GAT-1, -2 and -3). The GABA transporters function to terminate GABA action. |
| Immunogen | KLH conjugated synthetic peptide: human GABRA1 |
| Antigen Species | Human |
| Gene Name | GABRA1 |
| Gene ID | |
| Protein Name | gamma-aminobutyric acid receptor subunit alpha-1 |
| Uniprot ID | |
| Function | GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. |
| Molecular Weight | Theoretical: 52 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
γ-aminobutyric acid receptor subunit α-1γ-aminobutyric acid receptor subunit alpha-1γ-aminobutyric acid receptor subunit a-1Gamma-aminobutyric acid receptor subunit α-1Gamma-aminobutyric acid receptor subunit a-1G-aminobutyric acid receptor subunit α-1G-aminobutyric acid receptor subunit alpha-1G-aminobutyric acid receptor subunit a-1GABRA 1GABAAR subunit α-1GABAAR subunit α1GABAAR subunit alpha-1GABAAR subunit alpha1GABAAR subunit a-1GABAAR subunit a1GABA(A) receptor subunit α-1 (GABAAR subunit α-1)GABA(A) receptor subunit a-1 (GABAAR subunit a-1)
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