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Anti-GABRA1 Polyclonal Antibody
(Synonyms: Gamma-aminobutyric acid receptor subunit alpha-1, GABRA1, GABA(A) receptor subunit alpha-1 (GABAAR subunit alpha-1)) Copy Product Info
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Synonyms: Gamma-aminobutyric acid receptor subunit alpha-1, GABRA1, GABA(A) receptor subunit alpha-1 (GABAAR subunit alpha-1)
Catalog No. TMAB-00729 Copy Product Info
🥰Excellent
Anti-GABRA1 Polyclonal Antibody is a Rabbit antibody targeting GABRA1. Anti-GABRA1 Polyclonal Antibody can be used in IF, IHC-Fr, IHC-P, WB.
Anti-GABRA1 Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $373 | 7-10 days | 7-10 days | |
| 200 μL | $529 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-GABRA1 Polyclonal Antibody is a Rabbit antibody targeting GABRA1. Anti-GABRA1 Polyclonal Antibody can be used in IF, IHC-Fr, IHC-P, WB. |
| Synonyms | Gamma-aminobutyric acid receptor subunit alpha-1, GABRA1, GABA(A) receptor subunit alpha-1 (GABAAR subunit alpha-1) |
| Ig Type | IgG |
| Reactivity | Mouse,Rat (predicted:Human,Chicken,Dog,Cow,Horse) |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | Highly expressed in brain and weakly in heart, small intestine and uterus. Isoform 1A is mostly expressed in granular cell and molecular layer. Isoform 1B is mostly expressed in Purkinje cells. Isoform 1E is predominantly expressed in peripheral tissues a |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | GAD-65 and GAD-67, glutamate decarboxylases, function to catalyze the production of GABA (g-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl-conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct. Members of the GABAA receptor family include GABAA R alpha 1-6, GABAA R beta 1-3, GABAA R©1-3, GABAA R∂, GABAA R gamma, GABAA R delta 1 and GABAA R delta 2. The GABAB family is composed of GABAB R1 alpha and GABAB R1 beta. GABA transporters have also been identified and include GABA T-1, GABA T-2 and GABA T-3 (also designated GAT-1, -2 and -3). The GABA transporters function to terminate GABA action. |
| Immunogen | KLH conjugated synthetic peptide: human GABRA1 |
| Antigen Species | Human |
| Gene Name | GABRA1 |
| Gene ID | |
| Protein Name | gamma-aminobutyric acid receptor subunit alpha-1 |
| Uniprot ID | |
| Function | GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. |
| Molecular Weight | Theoretical: 52 kDa. Actual: 52 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Keywords
γ-aminobutyric acid receptor subunit α-1γ-aminobutyric acid receptor subunit alpha-1γ-aminobutyric acid receptor subunit a-1Gamma-aminobutyric acid receptor subunit α-1Gamma-aminobutyric acid receptor subunit a-1G-aminobutyric acid receptor subunit α-1G-aminobutyric acid receptor subunit alpha-1G-aminobutyric acid receptor subunit a-1GABRA 1GABAAR subunit α-1GABAAR subunit α1GABAAR subunit alpha-1GABAAR subunit alpha1GABAAR subunit a-1GABAAR subunit a1GABA(A) receptor subunit α-1 (GABAAR subunit α-1)GABA(A) receptor subunit a-1 (GABAAR subunit a-1)
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