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Guselkumab

Catalog No. T38362 CAS 1350289-85-8

Synonyms: CNTO 1959

Guselkumab (CNTO 1959) is a recombinant human IgG1 monoclonal antibody targeting the IL-23p19 subunit. Guselkumab binds to human cynomolgus monkey IL-23 with Kd values of 3.3 and 1.9 pmol/L, respectively. Guselkumab can inhibit the production of cytokines downstream of IL-23 signaling pathway, and can be used in the study of psoriatic arthritis.

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Guselkumab, CAS 1350289-85-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 663.00
5 mg	In stock	$ 2,320.00
10 mg	In stock	$ 3,120.00
25 mg	In stock	$ 4,630.00
50 mg	In stock	$ 6,270.00
100 mg	In stock	$ 8,460.00

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Biological Description

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Description	Guselkumab (CNTO 1959) is a recombinant human IgG1 monoclonal antibody targeting the IL-23p19 subunit. Guselkumab binds to human cynomolgus monkey IL-23 with Kd values of 3.3 and 1.9 pmol/L, respectively. Guselkumab can inhibit the production of cytokines downstream of IL-23 signaling pathway, and can be used in the study of psoriatic arthritis.
Targets&IC50	IL-23:0.06 nM (IC50), IL-23 (human):3.3 pM, IL-23 (monkey):1.9 pM, IL-23:0.06 pM(kd), STAT3 phosphorylation:102.1100±2.0053 nM
In vitro	Guselkumab effectively suppresses the production of Th17 cytokines, including IL17A, IL-17F, and IL-22, in mouse splenocytes stimulated with IL-23 concentrations of 0.5 or 1 ng/mL, demonstrating IC50 values between 0.016-0.080 nM. It also inhibits the IL-23 (10 or 100 ng/mL) driven production of IL-10 in human NKL cells. However, guselkumab does not impact the IL-12 (0.1 ng/mL) mediated production of interferon γ (IFNγ) in NK92MI cells. In combination with IBI112, guselkumab can prevent IL-23-induced STAT3 phosphorylation, showing an IC50 of 102.1100±2.0053 nM. Additionally, guselkumab blocks the induction of mIL-17 production by hIL-23 in a dose-dependent manner with an IC50 of 4.9743 ±1.2847 nM and inhibits IL-17F production in cynomolgus monkeys with an IC50 of 16.7950 nM.

Synonyms	CNTO 1959
Molecular Weight	N/A
Formula	N/A
CAS No.	1350289-85-8

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store at low temperature

store at -80°C

References and Literature

1. International non-proprietary name: guselkumab Procedure No. EMEA/H/C/004271/0000par-public-assessment-report_en.pdf 2. Li L, et al. IBI112, a selective anti-IL23p19 monoclonal antibody, displays high efficacy in IL-23-induced psoriasiform dermatitis. Int Immunopharmacol. 2020;89(Pt B):107008.

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Keywords

Guselkumab 1350289-85-8 Immunology/Inflammation IL Receptor CNTO1959 CNTO 1959 CNTO-1959 inhibitor inhibit

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