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Apelin-12 acetate
🥰Excellent
Catalog No. T39823L
Alias Apelin-12 acetate (229961-08-4 Free base)
Apelin-12 acetate possesses a high affinity to orphan receptor APJ receptor. Apelin-12 acetate inhibits the JNK and p38 MAPK signaling pathway of the apoptosis-related MAPKs family, thus offering protection to neurons.
Apelin-12 acetate
🥰Excellent
Purity: 98.82%
Catalog No. T39823LAlias Apelin-12 acetate (229961-08-4 Free base)
Apelin-12 acetate possesses a high affinity to orphan receptor APJ receptor. Apelin-12 acetate inhibits the JNK and p38 MAPK signaling pathway of the apoptosis-related MAPKs family, thus offering protection to neurons.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $228 | In Stock | |
| 5 mg | $320 | In Stock | |
| 10 mg | $497 | In Stock | |
| 25 mg | $793 | In Stock | |
| 50 mg | $1,130 | In Stock | |
| 100 mg | $1,520 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $797 | In Stock |
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Purity:98.82%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Apelin-12 acetate possesses a high affinity to orphan receptor APJ receptor. Apelin-12 acetate inhibits the JNK and p38 MAPK signaling pathway of the apoptosis-related MAPKs family, thus offering protection to neurons. |
| In vivo | Apelin-12 acetate significantly improves the neurobehavioral score of the mice with ischemia-reperfusion injury and alleviates brain edema and damage to neurons. Apelin-12 acetate inhibits the morphological changes and apoptosis of neuronal cells in the ischemic penumbra of mice. Apelin-12 acetate downregulates the expression of Bax and caspase-3, inhibits the activity of caspase-3, and upregulates the expression of Bcl-2, an anti-apoptotic protein[2]. |
| Synonyms | Apelin-12 acetate (229961-08-4 Free base) |
| Molecular Weight | 1482.75 |
| Formula | C66H107N21O16S |
| Smiles | CC(O)=O.O=C([C@H]1N(CCC1)C([C@@H](N)CCCNC(N)=N)=O)N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@H](C(N[C@H](C(NCC(N2[C@H](C(N[C@H](C(N3CCC[C@H]3C(N[C@H](C(O)=O)CC4=CC=CC=C4)=O)=O)CCSC)=O)CCC2)=O)=O)CCCCN)=O)CC5=CN=CN5)=O)=O)=O)CCCNC(N)=N |
| Color | White |
| Appearance | Solid |
| Sequence | H2N-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-COOH |
| Sequence Short | H2N-RPRLSHKGPMPF-OH |
Storage & Solubility Information
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 22.5 mg/mL (15.17 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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