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Anti-KEAP1 Antibody (8I308)
😃Good
Catalog No. TMAB-07982
Anti-KEAP1 Antibody (8I308) is a Rabbit antibody targeting KEAP1. Anti-KEAP1 Antibody (8I308) can be used in WB.
Anti-KEAP1 Antibody (8I308)
Anti-KEAP1 Antibody (8I308)
😃Good
Catalog No. TMAB-07982
Anti-KEAP1 Antibody (8I308) is a Rabbit antibody targeting KEAP1. Anti-KEAP1 Antibody (8I308) can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μL | $148 | 7-10 days | 7-10 days | |
| 50 μL | $261 | 7-10 days | 7-10 days | |
| 100 μL | $472 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-KEAP1 Antibody (8I308) is a Rabbit antibody targeting KEAP1. Anti-KEAP1 Antibody (8I308) can be used in WB. |
| Ig Type | IgG |
| Clone | 8I308 |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. Nucleus. Note=Shuttles between cytoplasm and nucleus. |
| Tissue Specificity | Broadly expressed, with highest levels in skeletal muscle. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008]. |
| Immunogen | KLH conjugated synthetic peptide: human KEAP1 |
| Antigen Species | Human |
| Gene Name | KEAP1 |
| Gene ID | |
| Protein Name | Kelch-like ECH-associated protein 1 |
| Uniprot ID | |
| Function | Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome. |
| Molecular Weight | Theoretical: 69 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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