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Buflomedil hydrochloride

Name: Buflomedil hydrochloride
Brand: TargetMol
SKU: T0317
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0317Cas No. 35543-24-9

Alias Loftyl, Fonzylane, Buflomedil HCl

Buflomedil hydrochloride (Fonzylane), a vasodilator, is used in therapy of claudication or the symptoms of the peripheral arterial disease.

Buflomedil hydrochloride

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Purity: 99.91%

Catalog No. T0317Alias Loftyl, Fonzylane, Buflomedil HClCas No. 35543-24-9

Buflomedil hydrochloride (Fonzylane), a vasodilator, is used in therapy of claudication or the symptoms of the peripheral arterial disease.

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$35	In Stock	In Stock
500 mg	$66	-	In Stock
1 g	$78	-	In Stock
5 g	$127	-	In Stock
10 g	$163	-	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.91%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Buflomedil hydrochloride (Fonzylane), a vasodilator, is used in therapy of claudication or the symptoms of the peripheral arterial disease.
Targets&IC50	α1B-adrenoceptor:6.84 μM (Ki), α1A-adrenoceptor (rat):4.06 μM (Ki)
In vitro	Buflomedil enhances intracellular cAMP levels in human keratinocytes, either secondary to adenyl-cyclase stimulation (BC) or phosphodiesterase inhibition (PTX). Buflomedil diminishes release of TPA-induced TNF-alpha and IL-8 in keratinocytes; in the case of IL-8, this inhibition may occur to transcriptional level. At the micromolar level, Buflomedil notably inhibits epinephrine-induced aggregation. Buflomedil leads to a weak inhibition of collagen- and ADP-induced aggregation. Buflomedil inhibits grainy secretion and the interaction of fibrinogen with its receptor on platelet. the capillary perfusion is improved by Buflomedil hypochloride in such related situations, evoking a possible effect upon neutrophils. Buflomedil Completely inhibits adhesion of histamine related neutrophil (flow system) and partially inhibits adhesion after IL-1-4 hours (flow and stable systems). Buflomedil lowers the hypoxia-induced neutrophil adhesion and expression of P-selectin at the surface of endothelial cells.
Synonyms	Loftyl, Fonzylane, Buflomedil HCl

Chemical Properties

Molecular Weight	343.85
Formula	C₁₇H₂₆ClNO₄
Cas No.	35543-24-9
Smiles	Cl.COc1cc(OC)c(C(=O)CCCN2CCCC2)c(OC)c1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 7 mg/mL (20.36 mM), Sonication is recommended.

H2O: 63 mg/mL (183.22 mM), Sonication is recommended.

DMSO: 50 mg/mL (145.41 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.82 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.9082 mL	14.5412 mL	29.0824 mL	145.4122 mL
5 mM	0.5816 mL	2.9082 mL	5.8165 mL	29.0824 mL
10 mM	0.2908 mL	1.4541 mL	2.9082 mL	14.5412 mL
20 mM	0.1454 mL	0.7271 mL	1.4541 mL	7.2706 mL

DMSO/H2O

	1mg	5mg	10mg	50mg
50 mM	0.0582 mL	0.2908 mL	0.5816 mL	2.9082 mL
100 mM	0.0291 mL	0.1454 mL	0.2908 mL	1.4541 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc