P2Y14R antagonist 2 (compound 39) is an effective and selective orally-active antagonist of P2Y14R with an IC50 of 0.40 nM. It exhibits anti-inflammatory properties and holds potential for use in studying colitis.

P2Y14 Receptor:0.40 nM

The compound P2Y14R antagonist 2, administered rectally at doses of 50 and 100 µM in a volume of 100µL to male C57BL/6 mice (colitis) for 7 days, exhibited anti-inflammatory effects in mice with colitis. This compound reduced symptoms such as DSS-induced body weight loss, loose stools, rectal bleeding, and colon shortening while also decreasing the spleen weight index.