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Atipamezole hydrochloride

Name: Atipamezole hydrochloride
Brand: TargetMol
SKU: T6765
Price: 47 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6765Cas No. 104075-48-1

Alias MPV-1248 hydrochloride, Antisedan

Atipamezole is a synthetic α2 adrenergic receptor antagonist. It has also been researched in humans as a potential anti-Parkinsonian drug. Atipamezole hydrochloride (MPV-1248 hydrochloride) is hydrochloride form of atipamezole.

Atipamezole hydrochloride

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Purity: 99.74%

Catalog No. T6765Alias MPV-1248 hydrochloride, AntisedanCas No. 104075-48-1

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$47	In Stock	In Stock
10 mg	$68	In Stock	In Stock
25 mg	$135	In Stock	In Stock
50 mg	$243	In Stock	In Stock
100 mg	$360	In Stock	In Stock
200 mg	$563	In Stock	In Stock
500 mg	$888	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$52	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.74%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Atipamezole is a synthetic α2 adrenergic receptor antagonist. It has also been researched in humans as a potential anti-Parkinsonian drug. Atipamezole hydrochloride (MPV-1248 hydrochloride) is hydrochloride form of atipamezole.
Targets&IC50	α2-adrenoceptor antagonist:1.6 nM（Ki）.
In vitro	The affinity of atipamezole for α2-adrenoceptors and its α2/α1 selectivity ratio are considerably higher than yohimbine. Atipamezole is not selective for subtypes of α2-adrenoceptors. It has negligible affinity for 5-HT1, 5-HT2 and I2 bindings sites[1].
In vivo	Atipamezole has been found to be well tolerated in rodents and displays only modest cardiovascular effects at dosages ranging from 0.01–1 mg/kg, administered intravenously, in anesthetized, normotensive rats. This compound is frequently utilized by veterinarians to reverse sedation or anesthesia in animals. Additionally, it has been observed to enhance sexual activity in both rats and monkeys. In situations of sustained nociception, atipamezole augments pain-related responses by inhibiting the noradrenergic feedback mechanism that normally suppresses pain. Furthermore, at low doses, atipamezole positively affects several cognitive functions in experimental animals, including alertness, selective attention, planning, learning, and recall, though its impact on short-term working memory remains unclear.
Synonyms	MPV-1248 hydrochloride, Antisedan

Chemical Properties

Molecular Weight	248.75
Formula	C₁₄H₁₆N₂·HCl
Cas No.	104075-48-1
Smiles	Cl.CCC1(Cc2ccccc2C1)c1cnc[nH]1
Relative Density.	1.115g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 16.67 mg/mL (67.02 mM), Sonication is recommended.

H2O: 24.9 mg/mL (100.1 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.04 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	4.0201 mL	20.1005 mL	40.2010 mL	201.0050 mL
5 mM	0.8040 mL	4.0201 mL	8.0402 mL	40.2010 mL
10 mM	0.4020 mL	2.0101 mL	4.0201 mL	20.1005 mL
20 mM	0.2010 mL	1.0050 mL	2.0101 mL	10.0503 mL
50 mM	0.0804 mL	0.4020 mL	0.8040 mL	4.0201 mL

H2O

	1mg	5mg	10mg	50mg
100 mM	0.0402 mL	0.2010 mL	0.4020 mL	2.0101 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc