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Xanthine Oxidase

Xanthine oxidase (XO, sometimes 'XAO') is a form of xanthine oxidoreductase, a type of enzyme that generates reactive oxygen species. These enzymes catalyze the oxidation of hypoxanthine to xanthine and can further catalyze the oxidation of xanthine to uric acid. These enzymes play an important role in the catabolism of purines in some species, including humans.

  • Phytic acid dodecasodium salt hydrate
    T16527123408-98-0
    Phytic acid dodecasodium salt hydrate (myo-Inositol, hexakis(dihydrogen phosphate) dodecasodium salt hydrate) is a phosphorus storage compound of seeds and cereal grains. Phytic acid dodecasodium salt hydrate inhibits the enzymatic superoxide source xanthine oxidase with an IC50 of 6 mM and has antioxidative, neuroprotective, and anti-inflammatory effects.
    • $50
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  • Xanthine oxidoreductase-IN-5
    T721661026652-90-3
    Xanthine oxidoreductase-IN-5 is an orally active xanthine oxidoreductase (XOR) inhibitor (IC50 : 55 nM).Xanthine oxidoreductase-IN-5 may be used in studies of acute hyperuricemia.
    • $85
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  • Xanthine oxidase-IN-1
    T105091071970-13-2In house
    Xanthine oxidase-IN-1 is an effective inhibitor of xanthine oxidase with an IC50 value of 6.5 nM. It plays a central role in purine catabolism through the degradation of bioactive nucleotides facilitated by nucleic acid and nucleotide intermediates.
    • $340
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  • Niraxostat
    T33676206884-98-2
    Niraxostat (Y-700) is one of the isocytosine derivatives as xanthine oxidase inhibitors.
    • $155
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  • Xanthine oxidoreductase-IN-4
    T720781026587-58-5
    Xanthine oxidoreductase-IN-4 is an orally active xanthine oxidoreductase (XOR) inhibitor that inhibits XOR with an IC50 value of 29.3 nM.Xanthine oxidoreductase-IN-4 can be used to study hyperuricemia.
    • $63
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  • amflutizole
    T856782114-19-0
    Amflutizole used for the treatment of gout, and is a Xanthine oxidase inhibitor
    • $133
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  • Xanthine oxidoreductase-IN-3
    T72165651769-78-7
    Xanthine oxidoreductase-IN-3 is an orally active xanthine oxidoreductase (XOR) inhibitor (IC50: 26.3 nM).Xanthine oxidoreductase-IN-3 can be used in acute hyperuricemia studies.
    • $258
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  • Forsythoside F
    TMA095894130-58-2
    Forsythoside F (Arenarioside) is a natural product, and GI50 values of 10-16 microM against B16F10 cell.
    • $146
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  • Tigulixostat
    T606251287766-55-5In house
    Tigulixostat (LC350189) is a novel xanthine oxidase inhibitor (XOI) that reduces uric acid production and may be used in studies of gout-related diseases.
    • $117 TargetMol
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  • Baicalein
    T2858491-67-8
    Baicalein (5,6,7-Trihydroxyflavone) is a xanthine oxidase inhibitor.
    • $33
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    TargetMol | Citations Cited
  • Allopurinol
    T0692315-30-0
    Allopurinol (Zyloric) is a Xanthine Oxidase Inhibitor. The mechanism of action of allopurinol is as a Xanthine Oxidase Inhibitor.
    • $50
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  • Nequinate
    T833713997-19-8
    Nequinate is an anticoccidial agent, preventing coccidiosis .
    • $39
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  • Febuxostat
    T0773144060-53-7
    Febuxostat (TEI 6720) is a xanthine oxidase Inhibitor.
    • $32
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    TargetMol | Citations Cited
  • Benzbromarone
    T12743562-84-3
    Benzbromarone (Desuric) is a CYP2C9 inhibitor with Ki value of 19.3 nM.
    • $33
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  • Blumeatin B
    TN352279995-67-8
    Blumeatin shows XO inhibitory activity.
    • $291
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  • Xanthine oxidase-IN-12
    T80767
    Xanthine oxidase-IN-12 (Compound 11), an inhibitor of xanthine oxidase (XO), possesses an IC50 value of 91 nM and exhibits antioxidant properties, additionally diminishing intracellular reactive oxygen species (ROS) [1].
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  • 8-Azaadenine
    T200421123-54-2
    8-Azaadenine (NSC-32797) is an inhibitor of xanthine oxidase with IC50 of 0.54 μM and Ki of 0.66 μM.
    • $30
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  • Myricetin 3-O-galactoside
    TN196215648-86-9
    Myricetin 3-O-galactoside (Myricetin 3-O-beta-D-galactopyranoside) can inhibit xanthine oxidase (xanthine oxidase; XO) activity, lipid peroxidation and scavenging free radicals. Myricetin 3-O-galactoside has many effects, including cytotoxicity, anti-oxidation, anti-genotoxicity, anti-infectivity, anti-inflammatory and antioxidant activities, and its main effect is to inhibit the synthesis of inducible nitric oxide synthase (iNOS). The IC50 of Myricetin 3-O-galactoside inhibited lipid peroxidation was 160 μg/mL.
    • $172
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  • 4-Hydroxyacetophenone
    T375099-93-4
    4-Hydroxyacetophenone (4-Acetylphenol) is a potent xanthine oxidase inhibitor.
    • $41
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  • URAT1&XO inhibitor 2
    T791771239488-96-0
    Compound BDEO (URAT1&XO inhibitor 2) serves as a dual-action inhibitor targeting both xanthine oxidase (XO) and URAT1, demonstrating an IC50 value of 3.3 μM for XO inhibition. It effectively impedes uric acid uptake in HEK293 cells with URAT1 expression, evidenced by a Ki of 0.145 μM. In hyperuricemic mice models, the compound has been shown to reduce serum urate levels and uric acid excretion, indicating potential utility for hyperuricemia research [1].
    • $1,520
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  • Antioxidant agent-13
    T79331
    Compound 5f (Antioxidant agent-13) is an antioxidant that demonstrates inhibition of DPPH and FRAP with half maximal inhibitory concentrations (IC50s) of 80.33 µM and 85.69 µM, respectively. Additionally, it inhibits the enzymes lipoxygenase (LOX) and xanthine oxidase (XO) with IC50s of 16.85 µM and 23.01 µM, respectively [1].
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  • Prudomestin
    T125643443-28-5
    Prudomestin (3,5,7-Trihydroxy-4',8-dimethoxyflavone) is a natural product isolated from the heartwood of Prunus domestica, with xanthine oxidase (XO) inhibitory activity with IC50 of 6 µM.
    • $98
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  • 6-Formylpterin
    T35976712-30-1
    6-Formylpterin (Pterin-6-aldehyde) is an inhibitor of Xanthine Oxidase (Ki ~0.6 nM) with potent neuroprotective effects against transient IRI in gerbils.6-Formylpterin induces intracellular ROS generation in HL-60 cells as well as apoptosis ( 6-Formylpterin inhibits the expression of iNOS, produces hydrogen peroxide intracellularly and restores the impaired bactericidal activity of human neutrophils.
    • $35
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  • Phytic acid
    T297183-86-3
    Phytic acid (Fytic Acid) is a complexing agent for removal of traces of heavy metal ions. It acts also as a hypocalcemic agent.
    • $40
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  • Fraxamoside
    TN4080326594-34-7
    Fraxamoside is a xanthine oxidase inhibitor (XOI) comparable in potency in vitro to the standard antigout drug allopurinol. It shows significant free radical scavenging effect against DPPH(EC50=62.6 uM).
    • $710
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  • Xanthine oxidase-IN-11
    T78985
    Xanthine Oxidase-IN-11, an analog of XO8, is an inhibitor of xanthine oxidase (XO) [1].
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  • URAT1&XO inhibitor 1
    T791752669726-78-5
    URAT1&XO Inhibitor 1 (compound 29) serves as a dual inhibitor with IC50 values of approximately 10 μM for URAT1 and 1.01 μM for Xanthine Oxidase. It induces a hypouricemic effect in the potassium oxonate-induced hyperuricemic rat model and is utilized in research pertaining to hyperuricemia [1].
    • $1,520
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  • Purpurogallin
    T16685569-77-7
    Purpurogallin is a naturally phenol extracted from the plants of Quercus spp. It has effective xanthine oxidase inhibitory activity (IC50: 0.2 µM). Purpurogallin also has antioxidant and anti-inflammatory effects.
    • $48
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  • Oxypurinol
    T16942465-59-0
    Oxypurinol is a xanthine oxidase inhibitor. Oxipurinol is potentially used for the treatment of congestive heart failure.
    • $30
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  • Tetrahydroamentoflavone
    TN513048236-96-0
    Tetrahydroamentoflavone is a potent XO inhibitor (IC50 = 92 nM, Ki = 982 nM) with anti-inflammatory effects. Tetrahydroamentoflavone can be used for studies about inflammation and gout.
    • $639
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  • Topiroxostat
    T2397577778-58-6
    Topiroxostat (FYX-051) is a selective xanthine oxidase inhibitor developed for treatment and management of hyperuricemia and gout.
    • $43
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