Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MDM2/XIAP-IN-1 (compound 14) is an orally active dual inhibitor of MDM2 and XIAP, exhibiting anti-cancer activity with an IC50 of 0.3 μM and potential applications in cancer research [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | Inquiry | Inquiry | |
50 mg | Inquiry | Inquiry |
Description | MDM2/XIAP-IN-1 (compound 14) is an orally active dual inhibitor of MDM2 and XIAP, exhibiting anti-cancer activity with an IC50 of 0.3 μM and potential applications in cancer research [1]. |
In vitro | The chemical compound MDM2/XIAP-IN-1, at a concentration of 0-4 μM administered over a period of 2 weeks, inhibits the cellular activity of EU-1, EU-3, NB-1643, SHEP, and LA1-55n cell lines [1]. |
In vivo | MDM2/XIAP-IN-1 Pharmacokinetic Profile in Male SD Rats [1] Pharmacokinetic Analysis [1]: Intravenous administration at a dose of 10 mg/kg resulted in an AUC_last of 4750 ng·h/mL, a half-life (t_1/2) of 0.94 hours, and an observed clearance (Cl_obs) of 2.12 L·h/kg. Oral dosing at 25 mg/kg exhibited an AUC_last of 0.71 ng·h/mL and a bioavailability (F) of 5.9%. |
Molecular Weight | N/A |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
MDM2/XIAP-IN-1 inhibitor inhibit