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S-(5'-Adenosyl)-L-methionine tosylate

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Catalog No. T4447Cas No. 52248-03-0
Alias SAMe, S-(5'-Adenosyl)-L-methionine p-toluenesulfonate salt

S-(5'-Adenosyl)-L-methionine tosylate (SAMe) is a ubiquitous methyl donor involved in a wide variety of biological reactions, including those mediated by DNA and protein methyltransferases [1]. S-(5'-Adenosyl)-L-methionine tosylate (SAMe) is a stable salt of SAM that is included in nutritional supplements for oral use [2]. S-(5'-Adenosyl)-L-methionine tosylate (SAMe) reportedly ameliorates depression, pain associated with osteoarthritis and fibromyalgia, and liver toxicity [3].

S-(5'-Adenosyl)-L-methionine tosylate
Other Forms of S-(5'-Adenosyl)-L-methionine tosylate:
S-Adenosyl-L-methionineT747529908-03-0
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S-(5'-Adenosyl)-L-methionine tosylate

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Purity: 98.18%
Catalog No. T4447Alias SAMe, S-(5'-Adenosyl)-L-methionine p-toluenesulfonate saltCas No. 52248-03-0
S-(5'-Adenosyl)-L-methionine tosylate (SAMe) is a ubiquitous methyl donor involved in a wide variety of biological reactions, including those mediated by DNA and protein methyltransferases [1]. S-(5'-Adenosyl)-L-methionine tosylate (SAMe) is a stable salt of SAM that is included in nutritional supplements for oral use [2]. S-(5'-Adenosyl)-L-methionine tosylate (SAMe) reportedly ameliorates depression, pain associated with osteoarthritis and fibromyalgia, and liver toxicity [3].
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
10 mg$30In StockIn Stock
25 mg$46In StockIn Stock
50 mg$67In StockIn Stock
100 mg$87In StockIn Stock
200 mg$137-In Stock
500 mg$277-In Stock
1 mL x 10 mM (in DMSO)$33In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:98.18%
Color:White to Yellow
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Product Introduction

Bioactivity
Description
S-(5'-Adenosyl)-L-methionine tosylate (SAMe) is a ubiquitous methyl donor involved in a wide variety of biological reactions, including those mediated by DNA and protein methyltransferases [1]. S-(5'-Adenosyl)-L-methionine tosylate (SAMe) is a stable salt of SAM that is included in nutritional supplements for oral use [2]. S-(5'-Adenosyl)-L-methionine tosylate (SAMe) reportedly ameliorates depression, pain associated with osteoarthritis and fibromyalgia, and liver toxicity [3].
SynonymsSAMe, S-(5'-Adenosyl)-L-methionine p-toluenesulfonate salt
Chemical Properties
Molecular Weight570.64
FormulaC22H30N6O8S2
Cas No.52248-03-0
SmilesCc1ccc(cc1)S([O-])(=O)=O.C[S+](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Relative Density.no data available
Storage & Solubility Information
Storagestore at low temperature,keep away from moisture,store under nitrogen | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 100 mg/mL (175.24 mM), Sonication is recommended.
DMSO: 45 mg/mL (78.86 mM), Sonication is recommended.
Solution Preparation Table
DMSO/H2O
1mg5mg10mg50mg
1 mM1.7524 mL8.7621 mL17.5242 mL87.6209 mL
5 mM0.3505 mL1.7524 mL3.5048 mL17.5242 mL
10 mM0.1752 mL0.8762 mL1.7524 mL8.7621 mL
20 mM0.0876 mL0.4381 mL0.8762 mL4.3810 mL
50 mM0.0350 mL0.1752 mL0.3505 mL1.7524 mL
H2O
1mg5mg10mg50mg
100 mM0.0175 mL0.0876 mL0.1752 mL0.8762 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

S(5'Adenosyl)Lmethionine tosylateS-(5'-Adenosyl)-L-methionine TosylateS-(5'-Adenosyl)-L-methionine p-toluenesulfonateS (5' Adenosyl) L methionine tosylate
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