Shopping Cart

Remove All

Your shopping cart is currently empty

Proceed to checkout Continue shopping

Levodropropizine

Name: Levodropropizine
Brand: TargetMol
SKU: T0217
Rating: 4.5 (1 reviews)

😃Good

Catalog No. T0217Cas No. 99291-25-5

Alias DF-526, (S)-(-)-Dropropizine

Levodropropizine ((S)-(-)-Dropropizine) is a histamine receptor inhibitor. It is used as an effective and very well tolerated peripheral antitussive drug.

Levodropropizine

😃Good

Purity: 99.93%

Catalog No. T0217Alias DF-526, (S)-(-)-DropropizineCas No. 99291-25-5

Levodropropizine ((S)-(-)-Dropropizine) is a histamine receptor inhibitor. It is used as an effective and very well tolerated peripheral antitussive drug.

Pack Size	Price	USA Warehouse	Global Warehouse
2 g	$30	Inquiry	Inquiry
5 g	$50	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.93%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Levodropropizine ((S)-(-)-Dropropizine) is a histamine receptor inhibitor. It is used as an effective and very well tolerated peripheral antitussive drug.
In vitro	Research indicates that Levodropropizine effectively suppresses cough in anesthetized guinea pigs and rabbits. Intravenous administration of Levodropizine in these animals, during mechanically and electrically induced coughs, shows an activity ranging from one-tenth to one-twentieth of codeine, similar to hydroxyzine. Oral Levodropizine treatment for cough induced by irritant aerosols has effects comparable to hydroxyzine and codeine. An intravenous dose of 15 mg/kg Levodropropizine reduces the duration of asphyxiation and the C-fiber response to phenylbiguanide. Additionally, Levodropropizine dose-dependently decreases capsaicin-induced Evans blue dye extravasation in rat airways.
In vivo	Levodropropizine exhibits affinity for both H1 histamine and α-adrenergic receptors.
Synonyms	DF-526, (S)-(-)-Dropropizine

Chemical Properties

Molecular Weight	236.31
Formula	C₁₃H₂₀N₂O₂
Cas No.	99291-25-5
Smiles	C([C@@H](CO)O)N1CCN(CC1)C2=CC=CC=C2
Relative Density.	1.168 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 44 mg/mL (186.2 mM), Sonication is recommended.

H2O: 12 mg/mL (50.78 mM), Sonication is recommended.

DMSO: 55 mg/mL (232.75 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.46 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.2317 mL	21.1586 mL	42.3173 mL	211.5865 mL
5 mM	0.8463 mL	4.2317 mL	8.4635 mL	42.3173 mL
10 mM	0.4232 mL	2.1159 mL	4.2317 mL	21.1586 mL
20 mM	0.2116 mL	1.0579 mL	2.1159 mL	10.5793 mL
50 mM	0.0846 mL	0.4232 mL	0.8463 mL	4.2317 mL

Ethanol/DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0423 mL	0.2116 mL	0.4232 mL	2.1159 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc